Antitumor Activity of Ethanolic Extract of Dendrobium formosum in T-Cell Lymphoma : An In Vitro and In Vivo Study
المؤلفون المشاركون
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-18
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Dendrobium, a genus of orchid, was found to possess useful therapeutic activities like anticancer, hypoglycaemic, antimicrobial, immunomodulatory, hepatoprotective, antioxidant, and neuroprotective activities.
The study was aimed to evaluate the anticancer property of the ethanolic extract of Dendrobium formosum on Dalton’s lymphoma.
In vitro cytotoxicity was determined by MTT assay, apoptosis was determined by fluorescence microscopy, and cell cycle progression was analysed using flow cytometry; in vivo antitumor activity was performed in Dalton’s lymphoma bearing mice.
The IC50 value of ethanolic extract was obtained at 350 μg/mL in Dalton’s lymphoma cells.
Fluorescence microscopy analysis showed significant increase in apoptotic cell death in dose- and time-dependent manner which was further confirmed through the resulting DNA fragmentation.
Further, flow cytometry analysis showed that the ethanolic extract arrests the cells in G2/M phase of the cell cycle.
The in vivo anticancer activity study illustrates significant increase in the survival time of Dalton’s lymphoma bearing mice on treatment with ethanolic extract when compared to control.
These results substantiate the antitumor properties of ethanolic extract of Dendrobium formosum and suggest an alternative in treatment of cancer.
Further studies are required regarding the isolation and characterization of bioactive components along with the analysis of molecular mechanism involved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Prasad, Ritika& Koch, Biplob. 2014. Antitumor Activity of Ethanolic Extract of Dendrobium formosum in T-Cell Lymphoma : An In Vitro and In Vivo Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-496048
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Prasad, Ritika& Koch, Biplob. Antitumor Activity of Ethanolic Extract of Dendrobium formosum in T-Cell Lymphoma : An In Vitro and In Vivo Study. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-496048
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Prasad, Ritika& Koch, Biplob. Antitumor Activity of Ethanolic Extract of Dendrobium formosum in T-Cell Lymphoma : An In Vitro and In Vivo Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-496048
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496048
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر