Circulating Cytokines and Histological Liver Damage in Chronic Hepatitis B Infection
المؤلفون المشاركون
Treeprasertsuk, Sombat
Komolmit, Piyawat
Poovorawan, Kittiyod
Poovorawan, Yong
Tangkijvanich, Pisit
Chirathaworn, Chintana
Wisedopas, Naruemon
المصدر
Hepatitis Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-31
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Each phase of hepatitis B infection stimulates distinct viral kinetics and host immune responses resulting in liver damage and hepatic fibrosis.
Our objective has been to correlate host inflammatory immune response including circulating Th1 and Th2 cytokines in patients with chronic hepatitis B infection with liver histopathology.
Sixty-four patients with chronic hepatitis B without previous treatment were recruited.
The liver histology and histological activity index were assessed for various degrees of necroinflammation and hepatic fibrosis.
We determined circulating levels of the Th1 and Th2 cytokines.
Forty-six males and 18 females at a median age of 34.5 years were studied.
HBeAg was present in 28/64 (43.75%) of the patients.
In patients negative for HBeAg, IL-10 and IFN-gamma were significantly correlated with degrees of necroinflammation (r=0.34, r=0.38, resp.; P<0.05).
Moreover, TNF-alpha was significantly correlated with degrees of fibrosis (r=0.35; P<0.05), and IL-10 and TNF-alpha were significantly correlated with significant fibrosis (r=0.39, r=0.35, resp.; P<0.05).
These correlations were found in the HBeAg negative group as opposed to the HBeAg positive group.
In HBeAg negative patients, circulating cytokines IL-10 and IFN-gamma were correlated with degrees of necroinflammation, whereas IL-10 and TNF-alpha were correlated with significant fibrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Poovorawan, Kittiyod& Tangkijvanich, Pisit& Chirathaworn, Chintana& Wisedopas, Naruemon& Treeprasertsuk, Sombat& Komolmit, Piyawat…[et al.]. 2013. Circulating Cytokines and Histological Liver Damage in Chronic Hepatitis B Infection. Hepatitis Research and Treatment،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-496325
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Poovorawan, Kittiyod…[et al.]. Circulating Cytokines and Histological Liver Damage in Chronic Hepatitis B Infection. Hepatitis Research and Treatment No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-496325
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Poovorawan, Kittiyod& Tangkijvanich, Pisit& Chirathaworn, Chintana& Wisedopas, Naruemon& Treeprasertsuk, Sombat& Komolmit, Piyawat…[et al.]. Circulating Cytokines and Histological Liver Damage in Chronic Hepatitis B Infection. Hepatitis Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-496325
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496325
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر