Mechanisms and Mediators of Inflammation : Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation
المؤلفون المشاركون
Wolfram, Dolores
Starzl, Ravi
Lee, W. P. Andrew
Pratschke, Johann
Grahammer, Johanna
Krapf, Christoph
Hautz, Theresa
Brandacher, Gerald
Schneeberger, Stefan
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Vascularized composite allotransplantation (VCA) is an effective treatment option for patients suffering from limb loss or severe disfigurement.
However, postoperative courses of VCA recipients have been complicated by skin rejection, and long-term immunosuppression remains a necessity for allograft survival.
To widen the scope of this quality-of-life improving procedure minimization of immunosuppression in order to limit risks and side effects is needed.
In some aspects, the molecular mechanisms and dynamics of skin allograft rejection seem similar to inflammatory skin conditions.
T cells are key players in skin rejection and are recruited to the skin via activation of adhesion molecules, cytokines, and chemokines.
Blocking these molecules has not only shown success in the treatment of inflammatory dermatoses, but also prolonged graft survival in various models of solid organ transplantation.
In addition to T cell recruitment, ectopic lymphoid structures within the allograft associated with chronic rejection in solid organ transplantation might contribute to the strong alloimmune response towards the skin.
Selectively targeting the molecules involved offers exciting novel therapeutic options in the prevention and treatment of skin rejection after VCA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hautz, Theresa& Wolfram, Dolores& Grahammer, Johanna& Starzl, Ravi& Krapf, Christoph& Pratschke, Johann…[et al.]. 2012. Mechanisms and Mediators of Inflammation : Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-496333
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hautz, Theresa…[et al.]. Mechanisms and Mediators of Inflammation : Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation. Clinical and Developmental Immunology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-496333
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hautz, Theresa& Wolfram, Dolores& Grahammer, Johanna& Starzl, Ravi& Krapf, Christoph& Pratschke, Johann…[et al.]. Mechanisms and Mediators of Inflammation : Potential Models for Skin Rejection and Targeted Therapy in Vascularized Composite Allotransplantation. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-496333
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496333
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر