Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet
المؤلفون المشاركون
Castrogiovanni, Daniel
Alzamendi, Ana
Del Zotto, Hector
Giovambattista, Andrés
Spinedi, Eduardo
Romero, Jose
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The intake of a fructose-rich diet (FRD) in the normal female rat induces features similar to those observed in the human metabolic syndrome phenotype.
We studied the impact of FRD administration to mothers on pregnancy outcome.
On gestational day (Gd) zero rats were assigned to either group: ad libitum drinking tap water alone (normal diet, ND) or containing fructose (10% w/vol; FRD) through pregnancy; all rats were fed a Purina chow diet ad libitum ND and FRD rats were daily cotreated or not with metformin (60 mg/Kg/day oral; ND + MF and FRD + MF) and submitted to a high glucose load test on Gd 14.
Additionally, placentas from different groups were studied on Gd 20.
Data indicated that: (1) although FRD rats well tolerated glucose overload, their circulating levels of insulin were significantly higher than in ND rats; (2) the mesometrial triangle blood vessel area was significantly lower in placentas from FRD than ND dams; (3) the detrimental effects of FRD administration to mothers were ameliorated by metformin cotreatment.
Our study suggests that excessive intake of fructose during pregnancy enhanced the risk for developing gestational diabetes and subsequent preeclampsia, and that metformin prevented the poor pregnancy outcome induced by FRD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alzamendi, Ana& Del Zotto, Hector& Castrogiovanni, Daniel& Romero, Jose& Giovambattista, Andrés& Spinedi, Eduardo. 2012. Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496378
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alzamendi, Ana…[et al.]. Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet. ISRN Endocrinology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-496378
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alzamendi, Ana& Del Zotto, Hector& Castrogiovanni, Daniel& Romero, Jose& Giovambattista, Andrés& Spinedi, Eduardo. Oral Metformin Treatment Prevents Enhanced Insulin Demand and Placental Dysfunction in the Pregnant Rat Fed a Fructose-Rich Diet. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-496378
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496378
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر