Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART
المؤلفون المشاركون
Worodria, William
Manabe, Yukari C.
Kestens, Luc
Mayanja-Kizza, Harriet
Namaganda, Jane
Kambugu, Andrew
Colebunders, Robert
Massinga-Loembe, Marguerite
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmasking of subclinical disease.
The subset of patients that are diagnosed with tuberculosis (TB) disease while on ART have been classified as ART-associated TB.
Few studies have reported the incidence of ART-associated TB and unmasking TB-IRIS according to the International Network for the Study of HIV-Associated IRIS (INSHI) consensus definition.
To determine the incidence and predictors of ART-associated TB, we screened 219 patients commencing ART at the Infectious Diseases Clinic in Kampala, Uganda for TB by symptoms, sputum microscopy, and chest X-rays and followed them for one year.
Fourteen (6.4%) patients were diagnosed with TB during followup.
Eight (3.8%) patients had ART-associated TB (incidence rate of 4.3 per 100 person years); of these, three patients fulfilled INSHI criteria for unmasking TB-associated IRIS (incidence rate of 1.6 per 100 person years).
A body mass index of less than 18.5 kg/m2 BMI (HR 5.85 95% CI 1.24–27.46, P=.025) and a C-reactive protein greater than 5 mg/L (HR 8.23 95% CI 1.36–38.33, P=.020) were risk factors for ART-associated TB at multivariate analysis.
In conclusion, with systematic TB screening (including culture and chest X-ray), the incidence of ART-associated TB is relatively low in settings with high HIV and TB prevalence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Worodria, William& Massinga-Loembe, Marguerite& Mayanja-Kizza, Harriet& Namaganda, Jane& Kambugu, Andrew& Manabe, Yukari C.…[et al.]. 2010. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-496421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Worodria, William…[et al.]. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-496421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Worodria, William& Massinga-Loembe, Marguerite& Mayanja-Kizza, Harriet& Namaganda, Jane& Kambugu, Andrew& Manabe, Yukari C.…[et al.]. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-496421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر