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Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART
المؤلفون المشاركون
Worodria, William
Manabe, Yukari C.
Kestens, Luc
Mayanja-Kizza, Harriet
Namaganda, Jane
Kambugu, Andrew
Colebunders, Robert
Massinga-Loembe, Marguerite
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Commencement of antiretroviral treatment (ART) in severely immunosuppressed HIV-infected persons is associated with unmasking of subclinical disease.
The subset of patients that are diagnosed with tuberculosis (TB) disease while on ART have been classified as ART-associated TB.
Few studies have reported the incidence of ART-associated TB and unmasking TB-IRIS according to the International Network for the Study of HIV-Associated IRIS (INSHI) consensus definition.
To determine the incidence and predictors of ART-associated TB, we screened 219 patients commencing ART at the Infectious Diseases Clinic in Kampala, Uganda for TB by symptoms, sputum microscopy, and chest X-rays and followed them for one year.
Fourteen (6.4%) patients were diagnosed with TB during followup.
Eight (3.8%) patients had ART-associated TB (incidence rate of 4.3 per 100 person years); of these, three patients fulfilled INSHI criteria for unmasking TB-associated IRIS (incidence rate of 1.6 per 100 person years).
A body mass index of less than 18.5 kg/m2 BMI (HR 5.85 95% CI 1.24–27.46, P=.025) and a C-reactive protein greater than 5 mg/L (HR 8.23 95% CI 1.36–38.33, P=.020) were risk factors for ART-associated TB at multivariate analysis.
In conclusion, with systematic TB screening (including culture and chest X-ray), the incidence of ART-associated TB is relatively low in settings with high HIV and TB prevalence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Worodria, William& Massinga-Loembe, Marguerite& Mayanja-Kizza, Harriet& Namaganda, Jane& Kambugu, Andrew& Manabe, Yukari C.…[et al.]. 2010. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-496421
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Worodria, William…[et al.]. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-496421
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Worodria, William& Massinga-Loembe, Marguerite& Mayanja-Kizza, Harriet& Namaganda, Jane& Kambugu, Andrew& Manabe, Yukari C.…[et al.]. Antiretroviral Treatment-Associated Tuberculosis in a Prospective Cohort of HIV-Infected Patients Starting ART. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-496421
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496421
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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