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Bovine Model of Doxorubicin-Induced Cardiomyopathy
المؤلفون المشاركون
Hamid, Tariq
Koenig, Steven C.
Giridharan, Guruprasad A.
Brittian, Kenneth R.
Prabhu, Sumanth D.
Bartoli, Carlo R.
المصدر
Journal of Biomedicine and Biotechnology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-12-30
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Left ventricular assist devices (LVADs) constitute a recent advance in heart failure (HF) therapeutics.
As the rigorous experimental assessment of LVADs in HF requires large animal models, our objective was to develop a bovine model of cardiomyopathy.
Male calves (n=8) were used.
Four animals received 1.2 mg/kg intravenous doxorubicin weekly for seven weeks and four separate animals were studied as controls.
Doxorubicin-treated animals were followed with weekly echocardiography.
Target LV dysfunction was defined as an ejection fraction ≤35%.
Sixty days after initiating doxorubicin, a terminal study was performed to determine hemodynamic, histological, biochemical, and molecular parameters.
All four doxorubicin-treated animals exhibited significant (P<0.05) contractile dysfunction, with target LV dysfunction achieved in three animals.
Doxorubicin-treated hearts exhibited significantly reduced coronary blood flow and interstitial fibrosis and significantly increased apoptosis and myocyte size.
Gene expression of atrial natriuretic factor increased more than 3-fold.
Plasma norepinephrine and epinephrine levels were significantly increased early and late during the development of cardiomyopathy, respectively.
We conclude that sequential administration of intravenous doxorubicin in calves induces a cardiomyopathy with many phenotypic hallmarks of the failing human heart.
This clinically-relevant model may be useful for testing pathophysiologic responses to LVADs in the context of HF.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bartoli, Carlo R.& Brittian, Kenneth R.& Giridharan, Guruprasad A.& Koenig, Steven C.& Hamid, Tariq& Prabhu, Sumanth D.. 2010. Bovine Model of Doxorubicin-Induced Cardiomyopathy. Journal of Biomedicine and Biotechnology،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bartoli, Carlo R.…[et al.]. Bovine Model of Doxorubicin-Induced Cardiomyopathy. Journal of Biomedicine and Biotechnology No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-496463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bartoli, Carlo R.& Brittian, Kenneth R.& Giridharan, Guruprasad A.& Koenig, Steven C.& Hamid, Tariq& Prabhu, Sumanth D.. Bovine Model of Doxorubicin-Induced Cardiomyopathy. Journal of Biomedicine and Biotechnology. 2010. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-496463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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