Possible Inhibitor from Traditional Chinese Medicine for the β Form of Calcium-Dependent Protein Kinase Type II in the Treatment of Major Depressive Disorder
المؤلفون المشاركون
Lee, Wen-Yuan
Chen, Kuen-Bao
Lee, Cheng-Chun
Chen, Calvin Yu-Chian
Chan, Yueh-Chiu
Huang, Hung-Jin
Hung, Tzu-Chieh
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-18
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Recently, an important topic of major depressive disorder (MDD) had been published in 2013.
MDD is one of the most prevalent and disabling mental disorders.
Consequently, much research is being undertaken into the causes and treatment.
It has been found that inhibition of the β form of calcium/calmodulin-dependent protein kinase type II (β-CaMKII) can ameliorate the disorder.
Upon screening the traditional Chinese medicine (TCM) database by molecular docking, sengesterone, labiatic acid, and methyl 3-O-feruloylquinate were selected for molecular dynamics.
After 20 ns simulation, the RMSD, total energy, and structure variation could define the protein-ligand interaction.
Furthermore, sengesterone, the principle candidate compound, has been found to have an effect on the regulation of emotions and memory development.
In structure variation, we find the sample functional group of important amino acids make the protein stable and have limited variation.
Due to similarity of structure variations, we suggest that these compounds may have an effect on β-CaMKII and that sengesterone may have a similar efficacy as the control.
However labiatic acid may be a stronger inhibitor of β-CaMKII based on the larger RMSD and variation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Huang, Hung-Jin& Chan, Yueh-Chiu& Lee, Cheng-Chun…[et al.]. 2014. Possible Inhibitor from Traditional Chinese Medicine for the β Form of Calcium-Dependent Protein Kinase Type II in the Treatment of Major Depressive Disorder. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-496736
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hung, Tzu-Chieh…[et al.]. Possible Inhibitor from Traditional Chinese Medicine for the β Form of Calcium-Dependent Protein Kinase Type II in the Treatment of Major Depressive Disorder. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-496736
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hung, Tzu-Chieh& Lee, Wen-Yuan& Chen, Kuen-Bao& Huang, Hung-Jin& Chan, Yueh-Chiu& Lee, Cheng-Chun…[et al.]. Possible Inhibitor from Traditional Chinese Medicine for the β Form of Calcium-Dependent Protein Kinase Type II in the Treatment of Major Depressive Disorder. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-496736
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496736
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر