![](/images/graphics-bg.png)
In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk
المؤلفون المشاركون
Ahmad, Saheem
Iqbal, Danish
Khan, Mohd. Sajid
Khan, M. Salman
Bagga, Paramdeep
Khan, Amir
Srivastava, Ashwani K.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-06
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Hypercholesterolemia-induced oxidative stress has been strongly implicated in the pathogenesis of atherosclerosis, which is one of the major causes of mortality worldwide.
The current work, for the first time, accounts the antioxidant, genoprotective, antilipoperoxidative, and HMG-CoA reductase (EC 1.1.1.34) inhibitory properties of traditional medicinal plant, Ficus palmata Forsk.
Our result showed that among sequentially extracted fractions of Ficus palmata Forsk, FPBA (F.
palmata bark aqueous extract) and FPLM (F.
palmata leaves methanolic extract) extracts have higher phenolic content and also exhibited significantly more radical scavenging (DPPH and Superoxide) and antioxidant (FRAP) capacity.
Moreover, FPBA extract also exhibited significantly higher inhibition of lipid peroxidation assay.
Additionally, results showed almost complete and partial protection of oxidatively damaged DNA by these plant extracts when compared to mannitol.
Furthermore, our results showed that FPBA extract (IC50=9.1±0.61 µg/mL) exhibited noteworthy inhibition of HMG-CoA reductase activity as compared to other extracts, which might suggest its role as cardioprotective agent.
In conclusion, results showed that FPBA extract not only possess significant antioxidant and genoprotective property but also is able to attenuate the enzymatic activity of HMG-CoA reductase, which might suggest its role in combating various oxidative stress-related diseases, including atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Iqbal, Danish& Khan, M. Salman& Khan, Amir& Khan, Mohd. Sajid& Ahmad, Saheem& Srivastava, Ashwani K.…[et al.]. 2014. In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-496805
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Iqbal, Danish…[et al.]. In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-496805
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Iqbal, Danish& Khan, M. Salman& Khan, Amir& Khan, Mohd. Sajid& Ahmad, Saheem& Srivastava, Ashwani K.…[et al.]. In Vitro Screening for β-Hydroxy-β-methylglutaryl-CoA Reductase Inhibitory and Antioxidant Activity of Sequentially Extracted Fractions of Ficus palmata Forsk. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-496805
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496805
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)