Long-Term Drug Survival of TNF Inhibitor Therapy in RA Patients : A Systematic Review of European National Drug Registers
المؤلفون المشاركون
Boyd, Helen
Porter, Duncan
Arora, Anamika
Mahajan, Anadi
Spurden, Dean
المصدر
International Journal of Rheumatology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
The present systematic review of RA registry data was undertaken to analyse the time on treatment of licensed TNF inhibitors in patients with RA in Europe.
Methods.
English language European registry studies comparing TNF inhibitors were searched using MEDLINE, Embase, Cochrane, and WHO: ICTRP up to 16 April 2012 and proceedings of three selected conferences held between 2010 and 2012.
Pooled analysis was performed to determine drug survival rates for each TNF inhibitor.
Results.
Sixteen studies met the inclusion criteria, of which 11 studies assessed biologic-naive patients and five studies included a mixed population of biologic-naive and biologic pretreated patients.
The overall effectiveness of TNF inhibitors diminished with time, leading to decreased drug survival rates.
Pooled drug survival rates after 60 months follow-up were 37% (infliximab), 48% (adalimumab), and 52% (etanercept).
Further, in an observational study, when TNF inhibitors were used in combination with methotrexate, a longer drug survival was observed compared to TNF inhibitors alone.
Conclusion.
The findings of this systematic review indicated numerically lower drug discontinuation rates with etanercept than adalimumab, whereas infliximab had the highest rate.
Further research is needed to understand the underlying mechanisms of treatment discontinuation with TNF inhibitors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arora, Anamika& Mahajan, Anadi& Spurden, Dean& Boyd, Helen& Porter, Duncan. 2013. Long-Term Drug Survival of TNF Inhibitor Therapy in RA Patients : A Systematic Review of European National Drug Registers. International Journal of Rheumatology،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496989
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arora, Anamika…[et al.]. Long-Term Drug Survival of TNF Inhibitor Therapy in RA Patients : A Systematic Review of European National Drug Registers. International Journal of Rheumatology No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-496989
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arora, Anamika& Mahajan, Anadi& Spurden, Dean& Boyd, Helen& Porter, Duncan. Long-Term Drug Survival of TNF Inhibitor Therapy in RA Patients : A Systematic Review of European National Drug Registers. International Journal of Rheumatology. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-496989
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-496989
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر