Modeling and Simulating Dynamics of Complete- and Poor-Response Chronic Hepatitis B Chinese Patients for Adefovir and Traditional Chinese Medicine Plus Adefovir Therapy
المؤلفون المشاركون
Chen, Xiao
Ru, Shuying
Min, Lequan
Zhang, Qun
Li, Xiaoke
Ye, Yongan
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-11-06
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
ChiCTR-TRC-11001263 study was the first large-scale double-blind randomized placebo-controlled traditional Chinese medicines (TCMs) and adefovir (ADV) antihepatitis B virus (HBV) infection trial in the world.
A total of 560 hepatitis B e antigen- (HBeAg-) positive Chinese patients with chronical HBV were randomly classified, in 1 : 1 ratio, into two groups: experimental group (EXG) receiving TCMs + ADV and controlled group (CTG) receiving ADV + TCM-placebo treatment for 48 weeks.
This paper introduces two models to model and simulate the evolutions of dynamics for the complete-response patients and the poor-response patients in EXG and CTG, respectively.
The stimulated mean HBV DNA and alanine aminotransferase (ALT) levels were close to the patients’ experimental data.
Analysis and simulations suggest that the activated patients’ immune functions by TCMs + ADV may not only clear infected hepatocytes, but also clear HBV, which made the complete-response patients’ mean serum HBV DNA levels in EXG reduce rapidly 12 weeks’ earlier than the ones in CTG.
One can assume that both the TCMs and ADV have the function of preventing complete-response patients’ infected hepatocytes from being injured by cytotoxic T lymphocytes (CTLs); the patients’ activated immune cells may also block HBV replications.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Min, Lequan& Chen, Xiao& Ye, Yongan& Zhang, Qun& Ru, Shuying& Li, Xiaoke. 2013. Modeling and Simulating Dynamics of Complete- and Poor-Response Chronic Hepatitis B Chinese Patients for Adefovir and Traditional Chinese Medicine Plus Adefovir Therapy. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497144
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Min, Lequan…[et al.]. Modeling and Simulating Dynamics of Complete- and Poor-Response Chronic Hepatitis B Chinese Patients for Adefovir and Traditional Chinese Medicine Plus Adefovir Therapy. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-497144
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Min, Lequan& Chen, Xiao& Ye, Yongan& Zhang, Qun& Ru, Shuying& Li, Xiaoke. Modeling and Simulating Dynamics of Complete- and Poor-Response Chronic Hepatitis B Chinese Patients for Adefovir and Traditional Chinese Medicine Plus Adefovir Therapy. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-497144
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497144
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر