Carbonic Anhydrase I as a New Plasma Biomarker for Prostate Cancer
المؤلفون المشاركون
Takakura, Michiko
Oda, Yoshinao
Imada, Kenjiro
Naito, Seiji
Tanaka, Yoshinori
Yamada, Tesshi
Miho, Banno
Kobayashi, Michimoto
Sakuma, Tomohiro
Jung, Giman
Kamita, Masahiro
Ono, Masaya
Honda, Kazufumi
Yokomizo, Akira
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-11-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Serum prostate-specific antigen (PSA) levels ranging from 4 to 10 ng/mL is considered a diagnostic gray zone for detecting prostate cancer because biopsies reveal no evidence of cancer in 75% of these subjects.
Our goal was to discover a new highly specific biomarker for prostate cancer by analyzing plasma proteins using a proteomic technique.
Enriched plasma proteins from 25 prostate cancer patients and 15 healthy controls were analyzed using a label-free quantitative shotgun proteomics platform called 2DICAL (2-dimensional image converted analysis of liquid chromatography and mass spectrometry) and candidate biomarkers were searched.
Among the 40,678 identified mass spectrum (MS) peaks, 117 peaks significantly differed between prostate cancer patients and healthy controls.
Ten peaks matched carbonic anhydrase I (CAI) by tandem MS.
Independent immunological assays revealed that plasma CAI levels in 54 prostate cancer patients were significantly higher than those in 60 healthy controls (P=0.022, Mann-Whitney U test).
In the PSA gray-zone group, the discrimination rate of prostate cancer patients increased by considering plasma CAI levels.
CAI can potentially serve as a valuable plasma biomarker and the combination of PSA and CAI may have great advantages for diagnosing prostate cancer in patients with gray-zone PSA level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Takakura, Michiko& Yokomizo, Akira& Tanaka, Yoshinori& Kobayashi, Michimoto& Jung, Giman& Miho, Banno…[et al.]. 2012. Carbonic Anhydrase I as a New Plasma Biomarker for Prostate Cancer. ISRN Oncology،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-497221
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Takakura, Michiko…[et al.]. Carbonic Anhydrase I as a New Plasma Biomarker for Prostate Cancer. ISRN Oncology No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-497221
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Takakura, Michiko& Yokomizo, Akira& Tanaka, Yoshinori& Kobayashi, Michimoto& Jung, Giman& Miho, Banno…[et al.]. Carbonic Anhydrase I as a New Plasma Biomarker for Prostate Cancer. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-497221
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497221
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر