Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity
المؤلفون المشاركون
Kozar, Michael P.
Reyes, Sean
Melendez, Victor
Wang, Hongxing
Li, Qigui
Hickman, Mark
Zhang, Jing
Xie, Lisa
المصدر
Malaria Research and Treatment
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-12
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Decoquinate (DQ) is highly effective at killing malaria parasites in vitro; however, it is extremely insoluble in water.
In this study, solid dispersion method was used for DQ formulation which created a suitable physical form of DQ in aqueous phase for particle manipulation.
Among many polymers and surfactants tested, polyvinylpyrrolidone 10, a polymer, and L-α-phosphatidylcholine or polysorbate, two surfactants, were chosen as DQ formulation components.
The formulation particles were reduced to a mean size between 200 to 400 nm, which was stable in aqueous medium for at least three weeks.
Pharmacokinetic (PK) studies showed that compared to DQ microparticle suspension, a nanoparticle formulation orally dosed to mice showed a 14.47-fold increase in area under the curve (AUC) of DQ plasma concentration and a 4.53-fold increase in AUC of DQ liver distribution.
WR 299666, a poorly water-soluble compound with antimalarial activity, was also tested and successfully made into nanoparticle formulation without undergoing solid dispersion procedure.
We concluded that nanoparticles generated by using appropriate formulation components and sufficient particle size reduction significantly increased the bioavailability of DQ and could potentially turn this antimalarial agent to a therapeutic drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Hongxing& Li, Qigui& Reyes, Sean& Zhang, Jing& Xie, Lisa& Melendez, Victor…[et al.]. 2013. Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity. Malaria Research and Treatment،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497319
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Hongxing…[et al.]. Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity. Malaria Research and Treatment No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-497319
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Hongxing& Li, Qigui& Reyes, Sean& Zhang, Jing& Xie, Lisa& Melendez, Victor…[et al.]. Formulation and Particle Size Reduction Improve Bioavailability of Poorly Water-Soluble Compounds with Antimalarial Activity. Malaria Research and Treatment. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-497319
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497319
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر