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AP-2α Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes
المؤلفون المشاركون
Yu, Lei
Domann, Frederick E.
Hitchler, Michael J.
Goswami, Prabhat C.
Sarsour, Ehab H.
Sun, Wenqing
Klingelhutz, Aloysius J.
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-12-24
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
AP-2α and c-MYC are important transcription factors involved in multiple cellular processes.
They each display the paradoxical capacities to stimulate both cell proliferation and apoptosis under different conditions.
In the present study we found that over expression of c-MYC was associated with accumulation of reactive oxygen species (ROS) and apoptosis in human keratinocytes, both of which were significantly inhibited by co-expression of AP-2.
The effects of AP-2 on c-MYC were active at several levels.
First, AP-2 and c-MYC were confirmed to interact at the protein level as previously described.
In addition, forced expression of AP-2 significantly decreased steady state levels of c-MYC mRNA and protein.
These findings suggested that AP-2 may have a direct effect on the c-myc gene.
Chromatin immunoprecipitation assays demonstrated that AP-2 proteins bound to a cluster of AP-2 binding sites located within a 2 kb upstream regulatory region of c-myc These results suggest that the negative regulation of AP-2 on c-MYC activity was achieved through binding of AP-2 protein to the c-myc gene.
The effects of AP-2 on c-MYC induced ROS accumulation and apoptosis in epidermal keratinocytes are likely to play an important role in cell growth, differentiation and carcinogenesis of the skin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Lei& Hitchler, Michael J.& Sun, Wenqing& Sarsour, Ehab H.& Goswami, Prabhat C.& Klingelhutz, Aloysius J.…[et al.]. 2009. AP-2α Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of Oncology،Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-497463
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Lei…[et al.]. AP-2α Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of Oncology No. 2009 (2009), pp.1-9.
https://search.emarefa.net/detail/BIM-497463
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Lei& Hitchler, Michael J.& Sun, Wenqing& Sarsour, Ehab H.& Goswami, Prabhat C.& Klingelhutz, Aloysius J.…[et al.]. AP-2α Inhibits c-MYC Induced Oxidative Stress and Apoptosis in HaCaT Human Keratinocytes. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-9.
https://search.emarefa.net/detail/BIM-497463
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497463
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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