Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1

المؤلفون المشاركون

Buckheit, Robert W.
Buckheit, Karen W.

المصدر

Molecular Biology International

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-07-12

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء

الملخص EN

Significant advancements in topical microbicide development have occurred since the prevention strategy was first described as a means to inhibit the sexual transmission of HIV-1.

The lack of clinical efficacy of the first generation microbicide products has focused development attention on specific antiretroviral agents, and these agents have proven partially successful in human clinical trials.

With greater understanding of vaginal and rectal virus infection, replication, and dissemination, better microbicide products and delivery strategies should result in products with enhanced potency.

However, a variety of development gaps exist which relate to product dosing, formulation and delivery, and pharmacokinetics and pharmacodynamics which must be better understood in order to prioritize microbicide products for clinical development.

In vitro, ex vivo, and in vivo models must be optimized with regard to these development gaps in order to put the right product at the right place, at the right time, and at the right concentration for effective inhibition of virus transmission.

As the microbicide field continues to evolve, we must harness the knowledge gained from unsuccessful and successful clinical trials and development programs to continuously enhance our preclinical development algorithms.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Buckheit, Karen W.& Buckheit, Robert W.. 2012. Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1. Molecular Biology International،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-497491

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Buckheit, Karen W.& Buckheit, Robert W.. Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1. Molecular Biology International No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-497491

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Buckheit, Karen W.& Buckheit, Robert W.. Factors Important to the Prioritization and Development of Successful Topical Microbicides for HIV-1. Molecular Biology International. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-497491

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-497491