Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after HypoxiaIschemia
المؤلفون المشاركون
Llovera, Gemma
Chertoff, Mariela
Shrivastava, Kalpana
Acarin, Laia
Recasens, Mireia
المصدر
Neurology Research International
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-28، 28ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-03
دولة النشر
مصر
عدد الصفحات
28
التخصصات الرئيسية
الملخص EN
Understanding the evolution of neonatal hypoxic/ischemic is essential for novel neuroprotective approaches.
We describe the neuropathology and glial/inflammatory response, from 3 hours to 100 days, after carotid occlusion and hypoxia (8% O2, 55 minutes) to the C57/BL6 P7 mouse.
Massive tissue injury and atrophy in the ipsilateral (IL) hippocampus, corpus callosum, and caudate-putamen are consistently shown.
Astrogliosis peaks at 14 days, but glial scar is still evident at day 100.
Microgliosis peaks at 3–7 days and decreases by day 14.
Both glial responses start at 3 hours in the corpus callosum and hippocampal fissure, to progressively cover the degenerating CA field.
Neutrophils increase in the ventricles and hippocampal vasculature, showing also parenchymal extravasation at 7 days.
Remarkably, delayed milder atrophy is also seen in the contralateral (CL) hippocampus and corpus callosum, areas showing astrogliosis and microgliosis during the first 72 hours.
This detailed and long-term cellular response characterization of the ipsilateral and contralateral hemisphere after H/I may help in the design of better therapeutic strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shrivastava, Kalpana& Chertoff, Mariela& Llovera, Gemma& Recasens, Mireia& Acarin, Laia. 2012. Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after HypoxiaIschemia. Neurology Research International،Vol. 2012, no. 2012, pp.1-28.
https://search.emarefa.net/detail/BIM-497512
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shrivastava, Kalpana…[et al.]. Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after HypoxiaIschemia. Neurology Research International No. 2012 (2012), pp.1-28.
https://search.emarefa.net/detail/BIM-497512
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shrivastava, Kalpana& Chertoff, Mariela& Llovera, Gemma& Recasens, Mireia& Acarin, Laia. Short and Long-Term Analysis and Comparison of Neurodegeneration and Inflammatory Cell Response in the Ipsilateral and Contralateral Hemisphere of the Neonatal Mouse Brain after HypoxiaIschemia. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-28.
https://search.emarefa.net/detail/BIM-497512
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497512
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر