The Potent In Vitro Skin Permeation of Archaeosome Made from Lipids Extracted of Sulfolobus acidocaldarius
المؤلفون المشاركون
Handali, Somayeh
Moghimipour, Eskandar
Ramezani, Zahra
Kargar, Mohammad
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Archaeosomes are a new generation of liposomes that exhibit higher stabilities under different conditions, such as high temperatures, alkaline or acidic pH, and presence of bile salts in comparison with liposomes, and can be used in biotechnology including drug, gene, and vaccine delivery.
The objective of this study was to prepare archaeosomes using lipid extracted from Sulfolobus acidocaldarius and evaluate their physicochemical properties.
The lipids were extracted from S.
acidocaldarius and assayed by High Performance Thin-Layer Chromatography (HPTLC).
Archaeosomes were prepared using film method and methylene blue was used as drug model.
They were characterized for their vesicle size and Differential Scanning Calorimetry (DSC) was used to investigate changes in their thermal behavior.
The released amount of methylene blue was determined using a dialysis membrane and rat skin.
HPTLC analysis of the extracted lipids showed that glycerol ether may be the major lipid with more than 78 percent probability.
Results of particle size determination showed a mean size of 158.33 nm and the results of DSC indicated the possible interaction of methylene blue with lipids during the preparation of archaeosome.
The addition of cholesterol significantly improved the encapsulation of methylene blue in the archaeosome so that the encapsulation efficiency was 61.66 ± 2.88%.
The result of in vitro skin permeation showed that methylene blue could pass through skin model according to Peppas model and there was about 41.66% release after 6 h, whereas no release was observed through dialysis membrane.
According to the results of the study, it is concluded that archaeosome may be successfully used as drug delivery system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Moghimipour, Eskandar& Kargar, Mohammad& Ramezani, Zahra& Handali, Somayeh. 2013. The Potent In Vitro Skin Permeation of Archaeosome Made from Lipids Extracted of Sulfolobus acidocaldarius. Archaea،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-497571
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Moghimipour, Eskandar…[et al.]. The Potent In Vitro Skin Permeation of Archaeosome Made from Lipids Extracted of Sulfolobus acidocaldarius. Archaea No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-497571
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Moghimipour, Eskandar& Kargar, Mohammad& Ramezani, Zahra& Handali, Somayeh. The Potent In Vitro Skin Permeation of Archaeosome Made from Lipids Extracted of Sulfolobus acidocaldarius. Archaea. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-497571
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497571
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر