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Outcomes of Severe Sepsis and Septic Shock Patients on Chronic Antiplatelet Treatment : A Historical Cohort Study
المؤلفون المشاركون
Jaffer, Insara J.
Valerio-Rojas, Juan C.
Gajic, Ognjen
Kor, Daryl J.
Cartin-Ceba, Rodrigo
المصدر
Critical Care Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-20
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Sepsis is characterized by dysfunctional activation of platelets, and antiplatelet therapy could improve the outcomes of septic patients.
Methods.
We performed a retrospective cohort study of severe sepsis or septic shock adult patients.
Outcomes of patients on antiplatelet therapy were compared to those that were not taking antiplatelet therapy by univariate analysis followed by a propensity score analysis based on the probability of receiving antiplatelet therapy.
Results.
Of 651 patients included in the study 272 (42.8%) were on antiplatelet therapy before the development of severe sepsis or septic shock.
After adjusting for important confounding variables antiplatelet therapy was not associated with a decreased risk of hospital mortality (odds ratio 0.73, 95% confidence interval 0.46–1.16).
Antiplatelet therapy was associated with a decreased incidence of acute respiratory distress syndrome/acute lung injury (odds ratio 0.50, 95% confidence interval 0.35–0.71) and reduced need of mechanical ventilation (odds ratio 0.62, 95% confidence interval 0.45–87).
Incidence of acute kidney injury was similar between both groups (odds ratio 1.08, 95% confidence interval 0.73–1.59).
Conclusions.
The use of antiplatelet therapy before the diagnosis of severe sepsis or septic shock was not associated with decreased hospital mortality.
Antiplatelet therapy was associated with a decreased incidence of acute lung injury/acute respiratory distress syndrome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Valerio-Rojas, Juan C.& Jaffer, Insara J.& Kor, Daryl J.& Gajic, Ognjen& Cartin-Ceba, Rodrigo. 2013. Outcomes of Severe Sepsis and Septic Shock Patients on Chronic Antiplatelet Treatment : A Historical Cohort Study. Critical Care Research and Practice،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-497637
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Valerio-Rojas, Juan C.…[et al.]. Outcomes of Severe Sepsis and Septic Shock Patients on Chronic Antiplatelet Treatment : A Historical Cohort Study. Critical Care Research and Practice No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-497637
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Valerio-Rojas, Juan C.& Jaffer, Insara J.& Kor, Daryl J.& Gajic, Ognjen& Cartin-Ceba, Rodrigo. Outcomes of Severe Sepsis and Septic Shock Patients on Chronic Antiplatelet Treatment : A Historical Cohort Study. Critical Care Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-497637
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497637
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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