Study of some antioxidants in plasma of patients with bladder cancer

الملخص EN

The objective of this study was to determine the catalase activity (CAT), ceruloplasmin activity (CP), glutathione level (GSH) in the plasma of (44) normal donars (22 male, 22 female,) and (66) patients with bladder cancer (22 smoker male, 22 non smoker male, 22 female).

Data analysis showed a significant decrease in the mean values of CAT (89.577 ± 17.140 of a smoker male, 92.102 ± 18.898 of non-smoker male, 90.225 ± 12.997 of a female) as compared to normal individuals (155.541 U / mg Hb of a male, 150.797 U / mg Hb of a female) respectively, and GSH (0.109 ± 0.056 of a smoker male, 0.110 ± 0.051 of non-smoker male, 0.084 ± 0.028 of a female) as compared to normal individuals (0.838 μmol/L of a male, 0.809 μmol / L of a female) respectively.

A significant increase in the mean value of CP in plasma of patients with bladder cancer (56.477 ± 2.671 of a smoker male, 55.602 ± 3.042 of non-smoker, 52.101 ± 3.212 of a female) was recorded as compared to normal individuals (43.908 IU of a male, 41.110 IU of a female) respectively, There is also a negative relationship between CAT & Cp and GSH & Cp levels (r = - 0.089, and r = - 0.104) respectively, while there is a positive relationship between CAT and GSH (r = 0.081) in-patients with bladder cancer.