Mucosal Melanomas of the Head and Neck : The Role of Postoperative Radiation Therapy
المؤلفون المشاركون
Markoe, Arnold M.
Saigal, Kunal
Reis, Isildinha M.
Nguyen-Sperry, Janet
Weed, Donald T.
Wolfson, Aaron H.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-04-11
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
Mucosal melanomas are rarer than their cutaneous counterparts and are associated with a poorer prognosis.
We report the clinical outcomes of patients with mucosal melanomas of the head and neck region generally treated with definitive surgery followed by postoperative radiation therapy (RT).
Methods.
We reviewed the records of 17 patients treated at the University of Miami in 1990–2007.
Patients generally received conventionally fractionated RT regimens to the postoperative bed.
Elective nodal RT was not routinely delivered.
Eight patients received adjuvant chemotherapy or immunotherapy.
Results.
Median followup was 35.2 months (range 5–225).
As the first site of failure: 3 patients recurred locally, 2 regionally and 2 distantly.
All 3 patients who recurred locally had not received RT.
Of the 5 locoregional recurrences, 4 were salvaged successfully with multimodality therapy with no evidence of disease at last followup.
Overall survival was 64.7% at 2 years and 51.5% at 5 years.
Conclusions.
Patients with mucosal melanoma of the head and neck are best treated with surgery to achieve negative margins, followed by postoperative RT to optimize local control.
Elective nodal irradiation may not be indicated in all cases, as regional failures were not predominant.
Distant metastases were fewer when compared to historical data, potentially due to advancements in adjuvant therapies as well as aggressive multi-modality salvage at time of failure.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Saigal, Kunal& Weed, Donald T.& Reis, Isildinha M.& Markoe, Arnold M.& Wolfson, Aaron H.& Nguyen-Sperry, Janet. 2012. Mucosal Melanomas of the Head and Neck : The Role of Postoperative Radiation Therapy. ISRN Oncology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-497889
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Saigal, Kunal…[et al.]. Mucosal Melanomas of the Head and Neck : The Role of Postoperative Radiation Therapy. ISRN Oncology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-497889
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Saigal, Kunal& Weed, Donald T.& Reis, Isildinha M.& Markoe, Arnold M.& Wolfson, Aaron H.& Nguyen-Sperry, Janet. Mucosal Melanomas of the Head and Neck : The Role of Postoperative Radiation Therapy. ISRN Oncology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-497889
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497889
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر