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Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection
المؤلفون المشاركون
Azzari, Chiara
Resti, Massimo
Olivito, Biagio
Indolfi, Giuseppe
Bartolini, Elisa
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-08
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Hepatitis C virus (HCV) infection has been associated with autoimmunity and extrahepatic manifestations in adults.
Few data are available on these topics in children.
Nonorgan specific auto-antibodies development is part of the natural course of chronic hepatitis C in children.
Smooth muscle autoantibody is the most common autoantibody found, while liver-kidney microsomal type-1 antibody positivity is the most peculiar autoimmune feature of children with HCV infection.
The clinical significance of non-organ specific autoantibodies in the course of paediatric chronic hepatitis C is still debated.
Autoantibody positivity can be considered neutral for most patients, while it can be associated with negative connotations for others, especially those positive for liver-kidney microsomal type-1 autoantibody.
Subclinical hypothyroidism but not autoimmune thyroiditis has been demonstrated in HCV infection in children, while only few cases of HCV-associated membranoproliferative glomerulonephritis have been described.
Single reports are available in the literature reporting the anecdotal association between chronic hepatitis C and other extrahepatic manifestations such as myopathy and opsoclonus-myoclonus syndrome.
Despite the low incidence of extrahepatic manifestations of chronic hepatitis C in children, overall, available data suggest a careful monitoring.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Indolfi, Giuseppe& Bartolini, Elisa& Olivito, Biagio& Azzari, Chiara& Resti, Massimo. 2012. Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-497934
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Indolfi, Giuseppe…[et al.]. Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection. Clinical and Developmental Immunology No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-497934
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Indolfi, Giuseppe& Bartolini, Elisa& Olivito, Biagio& Azzari, Chiara& Resti, Massimo. Autoimmunity and Extrahepatic Manifestations in Treatment-Naïve Children with Chronic Hepatitis C Virus Infection. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-497934
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497934
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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