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Diagnosis of Exclusion : A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis
المؤلفون المشاركون
Michaud, Christopher J.
Bockheim, Heather M.
Nabeel, Muhammad
Daum, Timothy E.
المصدر
Case Reports in Neurological Medicine
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-03
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Importance.
Medication-induced eosinophilia is an acknowledged, often self-limiting occurrence.
Glatiramer acetate, a biologic injection used in the management of relapsing-remitting multiple sclerosis, is widely regarded as a safe and effective medication and lists eosinophilia as an infrequent side effect in its package insert.
Contrary to reports of transient, benign drug-induced eosinophilia, we describe a case of probable glatiramer acetate-induced eosinophilia that ultimately culminated in respiratory distress, shock, and eosinophilic myocarditis.
Observations.
A 59-year-old female was admitted to the hospital after routine outpatient labs revealed leukocytosis (43,000 cells/mm3) with pronounced hypereosinophilia (63%).
This patient had been using glatiramer acetate without complication for over 10 years prior to admission.
Leukocytosis and hypereosinophilia persisted as a myriad of diagnostic evaluations returned negative, ultimately leading to respiratory depression, shock, and myocarditis.
Glatiramer acetate was held for the first time on day 6 of the hospital stay with subsequent resolution of leukocytosis, hypereosinophilia, respiratory distress, and shock.
Conclusions and Relevance.
Glatiramer acetate was probably the cause of this observed hypereosinophilia and the resulting complications.
Reports of glatiramer-induced eosinophilia are rare, and few case reports regarding medication-induced hypereosinophilia describe the severe systemic manifestations seen in this patient.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Michaud, Christopher J.& Bockheim, Heather M.& Nabeel, Muhammad& Daum, Timothy E.. 2014. Diagnosis of Exclusion : A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis. Case Reports in Neurological Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-497994
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Michaud, Christopher J.…[et al.]. Diagnosis of Exclusion : A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis. Case Reports in Neurological Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-497994
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Michaud, Christopher J.& Bockheim, Heather M.& Nabeel, Muhammad& Daum, Timothy E.. Diagnosis of Exclusion : A Case Report of Probable Glatiramer Acetate-Induced Eosinophilic Myocarditis. Case Reports in Neurological Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-497994
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-497994
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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