![](/images/graphics-bg.png)
Differences in Expression, Content, and Activity of 11β-HSD1 in Adipose Tissue between Obese Men and Women
المؤلفون المشاركون
Torres, A.
Mericq, Veronica
Ferrario, M.
Iñiguez, G.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Cortisol production in adipose tissue is regulated by 11β-HSD1.
Objective.
To determine whether there are differences in gene expression, enzyme activity, and protein content of the 11β-HSD1 enzyme in VAT (visceral adipose tissue) and SAT (subcutaneous adipose tissue) from obese compared to nonobese adults.
Methods.
VAT and SAT samples were obtained from 32 obese subjects (BMI>30 Kg/m2) who underwent bariatric surgery and 15 samples from controls submitted to elective surgery.
Fasting serum glucose, insulin, and lipids were measured.
The expression of 11β-HSD1 was determined by RT-PCR, the enzyme activity by thin-layer chromatography, and the protein content by Western blot.
Results.
Obese patients had higher cholesterol, insulin, and HOMA-IR compared to nonobese.
There were no differences in VAT or SAT expression of 11β-HSD1 between obese and nonobese patients.
However, we found lower 11β-HSD1 activity and protein content in VAT, in obese women versus nonobese women (P<0.05).
BMI and 11β-HSD1 enzyme activity and protein content in VAT correlated inversely in women.
Conclusions.
Regulation of 11β-HSD1 activity in VAT from obese subjects appears to be gender specific, suggesting the existence of a possible protective mechanism modulating this enzyme activity leading to a decrease in the production of cortisol in this tissue.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Torres, A.& Iñiguez, G.& Ferrario, M.& Mericq, Veronica. 2012. Differences in Expression, Content, and Activity of 11β-HSD1 in Adipose Tissue between Obese Men and Women. ISRN Endocrinology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498080
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Torres, A.…[et al.]. Differences in Expression, Content, and Activity of 11β-HSD1 in Adipose Tissue between Obese Men and Women. ISRN Endocrinology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-498080
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Torres, A.& Iñiguez, G.& Ferrario, M.& Mericq, Veronica. Differences in Expression, Content, and Activity of 11β-HSD1 in Adipose Tissue between Obese Men and Women. ISRN Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-498080
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498080
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)