Activity of Ceftaroline against Aerobic Gram-Positive and Gram-Negative Pathogens : Effect of Test Method Variability

الملخص EN

Ceftaroline is a new cephalosporin with bactericidal activity against methicillin-resistant S.

aureus (MRSA) as well as gram-negative pathogens.

Variations of in vitro test conditions were found to affect ceftaroline activity, with 5% NaCl inhibiting growth and/or reducing the minimum inhibitory concentrations (MICs) for E.

coli, K.

pneumoniae, M.

catarrhalis, H.

influenzae, and streptococci, while an inoculum of 106 CFU/mL raised MICs of some E.

coli, K.

pneumoniae, and M.

catarrhalis strains.