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Disturbances in the GlutathioneOphthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma
المؤلفون المشاركون
Zhang, Guo-Fang
Jacobs, G.
Abbas, R.
Sanabria, J. R.
Brunengraber, H.
Andres Ibarra, Rafael
Kombu, R. S.
Lee, Z.
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-09-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
The incidence of liver tumors is rising in USA.
The purpose of this study was to evaluate liver oxido-reductive status in the presence of chronic liver disease and hepatocellular carcinoma (HCC).
Methods.
Glutathione species and ophthalmate (OA) concentrations were measured by LC-MS in processed plasma and red blood cells (RBC) from infected Woodchuck with hepatitis virus (WHV).
Blood samples were obtained from: (i) infected animals with tumors (WHV+/HCC+), (ii) infected animals without tumors (WHV+/HCC−) and (iii) healthy animals (WHC−/HCC−).
Results.
The concentration of reduced glutathione (GSH) and the ratio GSH/GSG were lower in plasma from WHV+/HCC+ animals when compared to WHV+/HCC− and WHV−/HCC− (P<0.01).
In contrast, the concentration of oxidized glutathione (GSSG) was found to be higher in plasma from WHV+/HCC+ animals when compared to WHV+/HCC− and WHV−/HCC− (P<0.01).
The Glutathione species and its ratio from the RBC compartment were similar among all groups.
OA concentration in both plasma and RBC was significantly higher from WHV+/HCC+ when compared to WHV+/HCC− and WHV−/HCC− (P<0.01).
Conclusions.
Disturbances of the glutathione redox buffer system and higher concentrations of OA were found in the WCV+/HCC+ animal model.
The role of these compounds as biomarkers of early tumor development in patients with end stage liver disease remains to be determined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Andres Ibarra, Rafael& Abbas, R.& Kombu, R. S.& Zhang, Guo-Fang& Jacobs, G.& Lee, Z.…[et al.]. 2011. Disturbances in the GlutathioneOphthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma. HPB Surgery،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-498177
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Andres Ibarra, Rafael…[et al.]. Disturbances in the GlutathioneOphthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma. HPB Surgery No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-498177
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Andres Ibarra, Rafael& Abbas, R.& Kombu, R. S.& Zhang, Guo-Fang& Jacobs, G.& Lee, Z.…[et al.]. Disturbances in the GlutathioneOphthalmate Redox Buffer System in the Woodchuck Model of Hepatitis Virus-Induced Hepatocellular Carcinoma. HPB Surgery. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-498177
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498177
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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