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Modeling Innate Immune Response to Early Mycobacterium Infection
المؤلفون المشاركون
Kleijn, Jetty
Meijer, Annemarie H.
Carvalho, Rafael V.
Verbeek, Fons J.
المصدر
Computational and Mathematical Methods in Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-09
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In the study of complex patterns in biology, mathematical and computational models are emerging as important tools.
In addition to experimental approaches, these modeling tools have recently been applied to address open questions regarding host-pathogen interaction dynamics, including the immune response to mycobacterial infection and tuberculous granuloma formation.
We present an approach in which a computational model represents the interaction of the Mycobacterium infection with the innate immune system in zebrafish at a high level of abstraction.
We use the Petri Net formalism to model the interaction between the key host elements involved in granuloma formation and infection dissemination.
We define a qualitative model for the understanding and description of causal relations in this dynamic process.
Complex processes involving cell-cell or cell-bacteria communication can be modeled at smaller scales and incorporated hierarchically into this main model; these are to be included in later elaborations.
With the infection mechanism being defined on a higher level, lower-level processes influencing the host-pathogen interaction can be identified, modeled, and tested both quantitatively and qualitatively.
This systems biology framework incorporates modeling to generate and test hypotheses, to perform virtual experiments, and to make experimentally verifiable predictions.
Thereby it supports the unraveling of the mechanisms of tuberculosis infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Carvalho, Rafael V.& Kleijn, Jetty& Meijer, Annemarie H.& Verbeek, Fons J.. 2012. Modeling Innate Immune Response to Early Mycobacterium Infection. Computational and Mathematical Methods in Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498297
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Carvalho, Rafael V.…[et al.]. Modeling Innate Immune Response to Early Mycobacterium Infection. Computational and Mathematical Methods in Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-498297
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Carvalho, Rafael V.& Kleijn, Jetty& Meijer, Annemarie H.& Verbeek, Fons J.. Modeling Innate Immune Response to Early Mycobacterium Infection. Computational and Mathematical Methods in Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-498297
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498297
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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