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Potential Activity of 3-(2-Chlorophenyl)-1-phenyl-propenonein Accelerating Wound Healing in Rats
المؤلفون المشاركون
Salama, Suzy M.
Dhiyaaldeen, Summaya M.
Abdulla, Mahmood Ameen
Ismail, Salmah
al-Batran, Rami
Alwajeeh, Nahla S. I.
Alshawsh, Mohammed A.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Wound healing involves inflammation followed by granular tissue development and scar formation.
In this study, synthetic chalcone 3-(2-Chlorophenyl)-1-phenyl-propenone (CPPP) was investigated for a potential role in enhancing wound healing and closure.
Twenty-four male rats were divided randomly into 4 groups: carboxymethyl cellulose (CMC) (0.2 mL), Intrasite gel, and CPPP (25 or 50 mg/mL).
Gross morphology, wounds treatment with the CPPP, and Intrasite gel accelerate the rate of wound healing compared to CMC group.
Ten days after surgery, the animals were sacrificed.
Histological assessment revealed that the wounds treated with CPPP showed that wound closure site contained little amount of scar and the granulation tissue contained more collagen and less inflammatory cells than wound treated with CMC.
This finding was confirmed with Masson’s trichrome staining.
The antioxidant defence enzymes catalase (CAT) and superoxide dismutase (SOD) were significantly increased in the wound homogenates treated with CPPP (P<0.05) compared to CMC treated group.
However, in the CPPP treatment group, lipid peroxidation (MDA) was significantly decreased (P<0.05), suggesting that the CPPP also has an important role in protection against lipid peroxidation-induced skin injury after ten days of treatment with CPPP, which is similar to the values of cytokines TGF-β and TNF-α in tissue homogenate.
Finally the administration of CPPP at a dosage of 25 and 50 mg/kg was suitable for the stimulation of wound healing.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dhiyaaldeen, Summaya M.& Alshawsh, Mohammed A.& Salama, Suzy M.& Alwajeeh, Nahla S. I.& al-Batran, Rami& Ismail, Salmah…[et al.]. 2014. Potential Activity of 3-(2-Chlorophenyl)-1-phenyl-propenonein Accelerating Wound Healing in Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-498462
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dhiyaaldeen, Summaya M.…[et al.]. Potential Activity of 3-(2-Chlorophenyl)-1-phenyl-propenonein Accelerating Wound Healing in Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-498462
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dhiyaaldeen, Summaya M.& Alshawsh, Mohammed A.& Salama, Suzy M.& Alwajeeh, Nahla S. I.& al-Batran, Rami& Ismail, Salmah…[et al.]. Potential Activity of 3-(2-Chlorophenyl)-1-phenyl-propenonein Accelerating Wound Healing in Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-498462
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498462
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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