Subjects in a Population Study with High Levels of FENO Have Associated Eosinophil Airway Inflammation
المؤلفون المشاركون
Torén, Kjell
Riise, Gerdt C.
Olin, Anna-Carin
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-22
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Measurement of fraction of exhaled nitric oxide (FENO) is a promising tool to increase validity in epidemiological studies of asthma.
The association between airway inflammation and FENO has, however, only been examined in clinical settings and may be biased by selection of patients with asthma.
Methods.
In a population study with FENO registrations on 370 individuals, we identified nine subjects out of thirty subjects with high levels of FENO (>85th percentile, 30.3 ppb), irrespective of presence of respiratory symptoms, and 21 control subjects with FENO at median levels (11.1–16.4 ppb) willing to undergo bronchoscopy and bronchoalveolar lavage (BAL), all nonsmokers.
FENO was measured in accordance with ATS criteria, and the examination also included spirometry, methacholine challenge test, and sampling of exhaled breath condensate (EBC).
Results.
Subjects with high FENO levels had significantly higher median the percentage of eosinophils in BAL than controls (2.1 versus 0.6, P<.006), and there was a significant association between FENO and the percentage of eosinophils in BAL (ρ=0.6, P<.002) and ECP in BAL (ρ=0.65, P<.05) examining the whole group, but no association with gender, FEV1, or degree of metacholine sensitivity or any of the biomarkers in EBC.
All subjects with high FENO had respiratory symptoms, but only three had diagnosed asthma.
There were a significant association between hydrogen peroxide in EBC and the percentage of neutrophils in bronchial wash.
Conclusion.
High FENO levels signal asthmatic or allergic respiratory disease in a population-based study.
FENO levels are associated with degree of eosinophil airway inflammation as measured by the percentage of eosinophils and ECP in BAL.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Riise, Gerdt C.& Torén, Kjell& Olin, Anna-Carin. 2011. Subjects in a Population Study with High Levels of FENO Have Associated Eosinophil Airway Inflammation. ISRN Allergy،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-498500
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Riise, Gerdt C.…[et al.]. Subjects in a Population Study with High Levels of FENO Have Associated Eosinophil Airway Inflammation. ISRN Allergy No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-498500
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Riise, Gerdt C.& Torén, Kjell& Olin, Anna-Carin. Subjects in a Population Study with High Levels of FENO Have Associated Eosinophil Airway Inflammation. ISRN Allergy. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-498500
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498500
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر