Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery
المؤلفون المشاركون
Stepanova, Olga I.
Lioudyno, Victoria I.
Krylov, Andrei V.
Kisseleva, Ekaterina P.
المصدر
International Journal of Cell Biology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-07-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Tumors spontaneously develop central necroses due to inadequate blood supply.
Recent data indicate that dead cells and their products are immunogenic to the host.
We hypothesized that macrophage tumor-dependent reactions can be mediated differentially by factors released from live or dead tumor cells.
In this study, functional activity of resident peritoneal macrophages was investigated in parallel with tumor morphology during the growth of syngeneic nonimmunogenic hepatoma 22a.
Morphometrical analysis of tumor necroses, mitoses and leukocyte infiltration was performed in histological sections.
We found that inflammatory potential of peritoneal macrophages in tumor-bearing mice significantly varied depending on the stage of tumor growth and exhibited two peaks of activation as assessed by nitroxide and superoxide anion production, 5′-nucleotidase activity and pinocytosis.
Increased inflammatory reactions were not followed by the enhancement of angiogenic potential as assessed by Vascular Endothelial Growth Factor mRNA expression.
Phases of macrophage activity corresponded to the stages of tumor growth characterized by high proliferative potential.
The appearance and further development of necrotic tissue inside the tumor did not coincide with changes in macrophage behavior and therefore indirectly indicated that activation of macrophages was a reaction mostly to the signals produced by live tumor cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kisseleva, Ekaterina P.& Krylov, Andrei V.& Stepanova, Olga I.& Lioudyno, Victoria I.. 2011. Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-498537
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kisseleva, Ekaterina P.…[et al.]. Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery. International Journal of Cell Biology No. 2011 (2011), pp.1-14.
https://search.emarefa.net/detail/BIM-498537
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kisseleva, Ekaterina P.& Krylov, Andrei V.& Stepanova, Olga I.& Lioudyno, Victoria I.. Transplantable Subcutaneous Hepatoma 22a Affects Functional Activity of Resident Tissue Macrophages in Periphery. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-14.
https://search.emarefa.net/detail/BIM-498537
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498537
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر