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Novel Point Mutations and A8027G Polymorphism in Mitochondrial-DNA-Encoded Cytochrome c Oxidase II Gene in Mexican Patients with Probable Alzheimer Disease
المؤلفون المشاركون
Macías-Islas, Miguel Ángel
Loera-Castañeda, Verónica
Pacheco Moisés, Fermín Paul
Alatorre Jiménez, Moisés Alejandro
Célis de la Rosa, Alfredo
Velázquez-Brizuela, Irma E.
Sandoval-Ramírez, Lucila
Ortiz, Genaro Gabriel
Cortés-Enríquez, Fernando
González-Renovato, Erika Daniela
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Mitochondrial dysfunction has been thought to contribute to Alzheimer disease (AD) pathogenesis through the accumulation of mitochondrial DNA mutations and net production of reactive oxygen species (ROS).
Mitochondrial cytochrome c-oxidase plays a key role in the regulation of aerobic production of energy and is composed of 13 subunits.
The 3 largest subunits (I, II, and III) forming the catalytic core are encoded by mitochondrial DNA.
The aim of this work was to look for mutations in mitochondrial cytochrome c-oxidase gene II (MTCO II) in blood samples from probable AD Mexican patients.
MTCO II gene was sequenced in 33 patients with diagnosis of probable AD.
Four patients (12%) harbored the A8027G polymorphism and three of them were early onset (EO) AD cases with familial history of the disease.
In addition, other four patients with EOAD had only one of the following point mutations: A8003C, T8082C, C8201T, or G7603A.
Neither of the point mutations found in this work has been described previously for AD patients, and the A8027G polymorphism has been described previously; however, it hasn’t been related to AD.
We will need further investigation to demonstrate the role of the point mutations of mitochondrial DNA in the pathogenesis of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Loera-Castañeda, Verónica& Sandoval-Ramírez, Lucila& Pacheco Moisés, Fermín Paul& Macías-Islas, Miguel Ángel& Alatorre Jiménez, Moisés Alejandro& González-Renovato, Erika Daniela…[et al.]. 2014. Novel Point Mutations and A8027G Polymorphism in Mitochondrial-DNA-Encoded Cytochrome c Oxidase II Gene in Mexican Patients with Probable Alzheimer Disease. International Journal of Alzheimer's Disease،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-498681
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Loera-Castañeda, Verónica…[et al.]. Novel Point Mutations and A8027G Polymorphism in Mitochondrial-DNA-Encoded Cytochrome c Oxidase II Gene in Mexican Patients with Probable Alzheimer Disease. International Journal of Alzheimer's Disease No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-498681
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Loera-Castañeda, Verónica& Sandoval-Ramírez, Lucila& Pacheco Moisés, Fermín Paul& Macías-Islas, Miguel Ángel& Alatorre Jiménez, Moisés Alejandro& González-Renovato, Erika Daniela…[et al.]. Novel Point Mutations and A8027G Polymorphism in Mitochondrial-DNA-Encoded Cytochrome c Oxidase II Gene in Mexican Patients with Probable Alzheimer Disease. International Journal of Alzheimer's Disease. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-498681
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498681
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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