Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro : A Possible Mechanism to Promote Proteoglycans Synthesis
المؤلفون المشاركون
Chen, Liao-bin
Mei, Qi-bing
Li, Jing
Tan, Yang
Liu, Jun
Liu, Yan-song
Magdalou, Jacques
Li, Xiao-jun
Wang, Hui
Qin, Jun
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-04
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
This study investigated the effect of Angelica sinensis polysaccharides (APS-3c) on rat osteoarthritis (OA) model in vivo and rat interleukin-1-beta- (IL-1β-) stimulated chondrocytes in vitro.
APS-3c was administrated into rat OA knee joints and had protective effects on rat OA cartilage in vivo.
Primary rat articular chondrocytes were cotreated with APS-3c and IL-1β in vitro.
2~50 μg/mL APS-3c had no effect on chondrocytes viability, whereas it increased the proteoglycans (PGs) synthesis inhibited by IL-1β.
Microarray analysis showed that the significant changes were concentrated in the genes which were involved in PGs synthesis.
RT-PCR confirmed that treatment with APS-3c increased the mRNA expression of aggrecan and glycosyltransferases (GTs) inhibited by IL-1β but did not affect the mRNA expression of matrix-degrading enzymes.
These results indicate that APS-3c can improve PGs synthesis of chondrocytes on rat OA model in vivo and IL-1β-stimulated chondrocytes in vitro, which is due to the promotion of the expression of aggrecan and GTs involved in PGs synthesis but not the inhibition of the expression of matrix-degrading enzymes.
Our findings suggest the clinical relevance of APS-3c in the prospective of future alternative medical treatment for OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Qin, Jun& Liu, Yan-song& Liu, Jun& Li, Jing& Tan, Yang& Li, Xiao-jun…[et al.]. 2013. Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro : A Possible Mechanism to Promote Proteoglycans Synthesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-498703
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Qin, Jun…[et al.]. Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro : A Possible Mechanism to Promote Proteoglycans Synthesis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-498703
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Qin, Jun& Liu, Yan-song& Liu, Jun& Li, Jing& Tan, Yang& Li, Xiao-jun…[et al.]. Effect of Angelica sinensis Polysaccharides on Osteoarthritis In Vivo and In Vitro : A Possible Mechanism to Promote Proteoglycans Synthesis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-498703
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498703
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر