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Regulatory T Cells in Type 1 Autoimmune Pancreatitis
المؤلفون المشاركون
Okazaki, Kazuichi
Fukui, Yuri
Fukata, Norimasa
Fukui, Toshiro
Matsushita, Mitsunobu
Miyoshi, Hideaki
Shimatani, Masaaki
Nishio, Akiyoshi
Takaoka, Makoto
Koyabu, Masanori
Kusuda, Takeo
Ikeura, Tsukasa
Uchida, Kazushige
Sumimoto, Kimi
Sakaguchi, Yutaku
المصدر
International Journal of Rheumatology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Autoimmune pancreatitis (AIP) is a newly recognized pancreatic disorder.
Recently, International Consensus Diagnostic Criteria for AIP (ICDC) was published.
In this ICDC, AIP was classified into Type 1 and Type 2.
Patients with Type 1 AIP have several immunologic and histologic abnormalities specific to the disease, including increased levels of serum IgG4 and storiform fibrosis with infiltration of lymphocytes and IgG4-positive plasmacytes in the involved organs.
Among the involved organs showing extrapancreatic lesions, the bile duct is the most common, exhibiting sclerosing cholangitis (IgG4-SC).
However, the role of IgG4 is unclear.
Recently, it has been reported that regulatory T cells (Tregs) are involved in both the development of various autoimmune diseases and the shift of B cells toward IgG4, producing plasmacytes.
Our study showed that Tregs were increased in the pancreas with Type 1 AIP and IgG4-SC compared with control.
In the patients with Type 1 AIP and IgG4-SC, the numbers of infiltrated Tregs were significantly positively correlated with IgG4-positive plasma cells.
In Type 1 AIP, inducible costimulatory molecule (ICOS)+ and IL-10+ Tregs significantly increased compared with control groups.
Our data suggest that increased quantities of ICOS+ Tregs may influence IgG4 production via IL-10 in Type 1 AIP.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Uchida, Kazushige& Kusuda, Takeo& Koyabu, Masanori& Miyoshi, Hideaki& Fukata, Norimasa& Sumimoto, Kimi…[et al.]. 2012. Regulatory T Cells in Type 1 Autoimmune Pancreatitis. International Journal of Rheumatology،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498726
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Uchida, Kazushige…[et al.]. Regulatory T Cells in Type 1 Autoimmune Pancreatitis. International Journal of Rheumatology No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-498726
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Uchida, Kazushige& Kusuda, Takeo& Koyabu, Masanori& Miyoshi, Hideaki& Fukata, Norimasa& Sumimoto, Kimi…[et al.]. Regulatory T Cells in Type 1 Autoimmune Pancreatitis. International Journal of Rheumatology. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-498726
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498726
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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