Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia
المؤلفون المشاركون
Archer, Kellie J.
Brumelle, Jenni
Menzies, Victoria
Jackson-Cook, Colleen
Jones, Kimberly H.
Lyon, Debra E.
Gao, G.
Zhou, Qing
York, Timothy P.
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-08-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Fibromyalgia (FM), characterized by chronic widespread pain, fatigue, and cognitive/mood disturbances, leads to reduced workplace productivity and increased healthcare expenses.
To determine if acquired epigenetic/genetic changes are associated with FM, we compared the frequency of spontaneously occurring micronuclei (MN) and genome-wide methylation patterns in women with FM (n=10) to those seen in comparably aged healthy controls (n=42 (MN); n=8 (methylation)).
The mean (sd) MN frequency of women with FM (51.4 (21.9)) was significantly higher than that of controls (15.8 (8.5)) (χ2=45.552; df = 1; P=1.49×10-11).
Significant differences (n=69 sites) in methylation patterns were observed between cases and controls considering a 5% false discovery rate.
The majority of differentially methylated (DM) sites (91%) were attributable to increased values in the women with FM.
The DM sites included significant biological clusters involved in neuron differentiation/nervous system development, skeletal/organ system development, and chromatin compaction.
Genes associated with DM sites whose function has particular relevance to FM included BDNF, NAT15, HDAC4, PRKCA, RTN1, and PRKG1.
Results support the need for future research to further examine the potential role of epigenetic and acquired chromosomal alterations as a possible biological mechanism underlying FM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Menzies, Victoria& Lyon, Debra E.& Archer, Kellie J.& Zhou, Qing& Brumelle, Jenni& Jones, Kimberly H.…[et al.]. 2013. Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia. Nursing Research and Practice،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498794
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Menzies, Victoria…[et al.]. Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia. Nursing Research and Practice No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-498794
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Menzies, Victoria& Lyon, Debra E.& Archer, Kellie J.& Zhou, Qing& Brumelle, Jenni& Jones, Kimberly H.…[et al.]. Epigenetic Alterations and an Increased Frequency of Micronuclei in Women with Fibromyalgia. Nursing Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-498794
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498794
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر