![](/images/graphics-bg.png)
The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target
المؤلف
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-19
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأمراض
الملخص EN
The abnormal deposition of proteins in and around neurons is a common pathological feature of many neurodegenerative diseases.
Among these pathological proteins, the microtubule-associated protein tau forms intraneuronal filaments in a spectrum of neurological disorders.
The discovery that dominant mutations in the MAPT gene encoding tau are associated with familial frontotemporal dementia strongly supports abnormal tau protein as directly involved in disease pathogenesis.
This and other evidence suggest that tau is a worthwhile target for the prevention or treatment of tau-associated neurodegenerative diseases, collectively called tauopathies.
However, it is critical to understand the normal biological roles of tau, the specific molecular events that induce tau to become neurotoxic, the biochemical nature of pathogenic tau, the means by which pathogenic tau exerts neurotoxicity, and how tau pathology propagates.
Based on known differences between normal and abnormal tau, a number of approaches have been taken toward the discovery of potential therapeutics.
Key questions still remain open, such as the nature of the connection between the amyloid-β protein of Alzheimer’s disease and tau pathology.
Answers to these questions should help better understand the nature of tauopathies and may also reveal new therapeutic targets and strategies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wolfe, Michael S.. 2012. The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target. Scientifica،Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-498822
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wolfe, Michael S.. The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target. Scientifica No. 2012 (2012), pp.1-20.
https://search.emarefa.net/detail/BIM-498822
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wolfe, Michael S.. The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target. Scientifica. 2012. Vol. 2012, no. 2012, pp.1-20.
https://search.emarefa.net/detail/BIM-498822
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498822
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)