Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency : Implications for Cardiovascular Disease Risk
المؤلفون المشاركون
McNamara, Robert K.
Pandey, Ghanshyam N.
Dwivedi, Yogesh
Rider, Therese
Jandacek, Ronald
Tso, Patrick
المصدر
Cardiovascular Psychiatry and Neurology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Deficiency in long-chain omega-3 (LCn − 3) fatty acids, eicosapentaenoic acid (EPA, 20:5n − 3) and docosahexaenoic acid (DHA, 22:6n − 3), has been implicated in the pathoetiology of cardiovascular disease, a primary cause of excess premature mortality in patients with schizophrenia (SZ).
In the present study, we determined erythrocyte EPA + DHA levels in adult medication-free patients SZ (n=20) and age-matched healthy controls (n=24).
Erythrocyte EPA + DHA composition exhibited by SZ patients (3.5%) was significantly lower than healthy controls (4.5%, −22%, P=0.007).
The majority of SZ patients (72%) exhibited EPA+DHA levels ≤4.0% compared with 37% of controls (Chi-square, P=0.001).
In contrast, the omega-6 fatty acid arachidonic acid (AA, 20:4n−6) (+9%, P=0.02) and the AA:EPA + DHA ratio (+28%, P=0.0004) were significantly greater in SZ patients.
Linoleic acid (18:2n−6) was significantly lower (−12%, P=0.009) and the erythrocyte 20:3/18:2 ratio (an index of delta6-desaturase activity) was significantly elevated in SZ patients.
Compared with same-gender controls, EPA + DHA composition was significantly lower in male (−19%, P=0.04) but not female (−13%, P=0.33) SZ patients, whereas the 20:3/18:2 ratio was significantly elevated in both male (+22%, P=0.008) and female (+22%, P=0.04) SZ patients.
These results suggest that the majority of SZ patients exhibit low LCn − 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
McNamara, Robert K.& Jandacek, Ronald& Rider, Therese& Tso, Patrick& Dwivedi, Yogesh& Pandey, Ghanshyam N.. 2013. Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency : Implications for Cardiovascular Disease Risk. Cardiovascular Psychiatry and Neurology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498864
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
McNamara, Robert K.…[et al.]. Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency : Implications for Cardiovascular Disease Risk. Cardiovascular Psychiatry and Neurology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-498864
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
McNamara, Robert K.& Jandacek, Ronald& Rider, Therese& Tso, Patrick& Dwivedi, Yogesh& Pandey, Ghanshyam N.. Adult Medication-Free Schizophrenic Patients Exhibit Long-Chain Omega-3 Fatty Acid Deficiency : Implications for Cardiovascular Disease Risk. Cardiovascular Psychiatry and Neurology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-498864
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498864
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر