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Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats
المؤلفون المشاركون
Chang, Chen-Kuei
Yeh, Ching-Hua
Cheng, Kai-Chun
Zhang, Ying Wen
Li, Ying-Xiao
Cheng, Juei-Tang
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Hyperglycemia induced reactive oxygen species (ROS) generation is believed as major factors leading to diabetic nephropathy (DN).
DangGui (Angelica sinensis) is mentioned to show renal protective effect in combination with other herbs.
Bone morphogenetic proteins-7 (BMP-7) is produced merit in protection of DN.
The role of BMP-7 in DangGui-induced renal improvement is not clear.
The present study investigated the effects of DangGui on renal functions, BMP-7 expression and the levels of ROS in streptozotocin (STZ)-induced diabetic rats and high glucose-exposed rat mesangial cells (RMCs).
After 1- or 4-week treatment, DangGui improved renal functions and increased renal BMP-7 expression in diabetic rats.
The BMP-7 expression in RMCs was reduced by high glucose treatment and this could be reversed by DangGui.
Moreover, RMCs exposed to high glucose were expired by BMP-7 RNAi transfection but those cells remained alive by scramble transfection.
Thus, we employed regular RMCs to knock down BMP-7 with RNAi and we found that DangGui increased BMP-7 expression in these RMCs.
Direct activation of BMP-7 expression by DangGui could be considered.
The results of DPPH assay, DHE stain and lucigenin assay indicated that DangGui could inhibit high glucose-induced ROS in RMCs.
These results suggest that DangGui has an ability to improve renal functions in STZ-diabetic rats through increasing endogenous BMP-7 expression and decreasing oxidative stress in kidney.
The present study suggest that DangGui could be applied to improve renal functions in diabetic disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yeh, Ching-Hua& Chang, Chen-Kuei& Cheng, Kai-Chun& Li, Ying-Xiao& Zhang, Ying Wen& Cheng, Juei-Tang. 2011. Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-498876
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yeh, Ching-Hua…[et al.]. Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-498876
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yeh, Ching-Hua& Chang, Chen-Kuei& Cheng, Kai-Chun& Li, Ying-Xiao& Zhang, Ying Wen& Cheng, Juei-Tang. Role of Bone Morphogenetic Proteins-7 (BMP-7) in the Renal Improvement Effect of DangGui (Angelica sinensis) in Type-1 Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-498876
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-498876
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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