Correlating Pap Smear Results and Colposcopy-Directed Large Loop Excision of the Transformation Zone Histopathology in HIV-Infected and HIV-Uninfected Women : A Case-Control Study in South Africa
المؤلف
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-24
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
In low-resource settings (LRS) with high HIV/AIDS and cervical cancer rates, new screening strategies face many logistic hurdles.
Since cytology is there to stay, at least in the median-term future, it is important to assess to what extent HIV-HPV coinfection impacts the accuracy of screening methods and strategies.
Methods.
We audited the correlation between cytological diagnosis of minimal abnormality (≤CIN1), CIN2+, or cancer and the histological diagnosis of colposcopy-directed large loop excision of the transformation zone of 399 HIV-uninfected controls and 389 HIV-infected cases.
Results.
The average age at diagnosis of CIN2+ of the cases was 4.2 years younger than controls (P<0.0001).
The endpoint used to assess the accuracy of cytology was minimal cytological abnormality (≤CIN1/LGSIL).
The sensitivity, specificity, and negative and positive predictive values were 92.7, 18.5, 45.1, and 77.9%, respectively.
The overall ratio of discordance/concordance between cytology and histology was similar in both groups.
Conclusion.
In LRS, where rapid-HPV testing is not yet part of screening algorithms, a cytological diagnosis of minimal abnormality requires visual inspection and treatment of visualized lesions especially in HIV-infected women aged ≤30 years.
The cytological endpoint of accuracy should be set low to avoid false negative smears.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
van Bogaert, Louis-Jacques. 2013. Correlating Pap Smear Results and Colposcopy-Directed Large Loop Excision of the Transformation Zone Histopathology in HIV-Infected and HIV-Uninfected Women : A Case-Control Study in South Africa. Journal of Cancer Research،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-499084
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
van Bogaert, Louis-Jacques. Correlating Pap Smear Results and Colposcopy-Directed Large Loop Excision of the Transformation Zone Histopathology in HIV-Infected and HIV-Uninfected Women : A Case-Control Study in South Africa. Journal of Cancer Research No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-499084
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
van Bogaert, Louis-Jacques. Correlating Pap Smear Results and Colposcopy-Directed Large Loop Excision of the Transformation Zone Histopathology in HIV-Infected and HIV-Uninfected Women : A Case-Control Study in South Africa. Journal of Cancer Research. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-499084
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499084
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر