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Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma
المؤلفون المشاركون
Santarpia, Libero
Antonelli, Alessandro
Giunti, Serena
Amorosi, Andrea
المصدر
International Journal of Endocrinology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-21
دولة النشر
مصر
عدد الصفحات
16
التخصصات الرئيسية
الملخص EN
Parafollicular C-cell-derived medullary thyroid cancer (MTC) comprises 3% to 4% of all thyroid cancers.
While cytotoxic treatments have been shown to have limited efficacy, targeted molecular therapies that inhibit rearranged during transfection (RET) and other tyrosine kinase receptors that are mainly involved in angiogenesis have shown great promise in the treatment of metastatic or locally advanced MTC.
Multi-tyrosine kinase inhibitors such as vandetanib, which is already approved for the treatment of progressive MTC, and cabozantinib have shown distinct advantages with regard to rates of disease response and control.
However, these types of tyrosine kinase inhibitor compounds are able to concurrently block several types of targets, which limits the understanding of RET as a specific target.
Moreover, important resistances to tyrosine kinase inhibitors can occur, which limit the long-term efficacy of these treatments.
Deregulated cellular signaling pathways and genetic alterations in MTC, particularly the activation of the RAS/mammalian target of rapamycin (mTOR) cascades and RET crosstalk signaling, are now emerging as novel and potentially promising therapeutic treatments for aggressive MTC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giunti, Serena& Antonelli, Alessandro& Amorosi, Andrea& Santarpia, Libero. 2013. Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-499277
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giunti, Serena…[et al.]. Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma. International Journal of Endocrinology No. 2013 (2013), pp.1-16.
https://search.emarefa.net/detail/BIM-499277
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giunti, Serena& Antonelli, Alessandro& Amorosi, Andrea& Santarpia, Libero. Cellular Signaling Pathway Alterations and Potential Targeted Therapies for Medullary Thyroid Carcinoma. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-16.
https://search.emarefa.net/detail/BIM-499277
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499277
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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