Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome
المؤلفون المشاركون
Tseng, Chia-Cheng
Leung, Sum-Yee
Chang, Huang-Chih
Lin, Meng-Chih
Wang, Chin-Chou
Chen, Hung-Chen
Chang, Ya-Chun
Fang, Wen-Feng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-03
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objectives.
This study aimed to identify the independent biomarkers and clinical factors that could predict ICU mortality and 6-month outcomes in relatively healthy patients with severe pneumonia and acute respiratory distress syndrome (ARDS).
Patients and Methods.
We prospectively enrolled patients with severe pneumonia-related ARDS that required mechanical ventilation.
Patients were excluded if they were unable to take care of themselves.
Several biomarkers and clinical factors were evaluated prospectively on day 1 and day 3 after ICU admission.
All biomarkers and clinical factors were collected for analysis.
Results.
56 patients were enrolled in this study.
We determined that the initial appropriate antibiotics use was an independent clinical factor and day 1 high-mobility group protein B1 (HMGB1) concentration was an independent biomarker for ICU mortality.
Interestingly, we also found that a low day 1 albumin level was an independent biomarker for predicting patient life dependence 6 months after a pneumonia event.
Conclusion.
Patients with severe pneumonia and ARDS requiring mechanical ventilation experience high rates of ICU mortality or disability, even if they were quite healthy before.
Initial appropriate antibiotics use and day 1 level of HMGB1 were independent factors for predicting ICU mortality.
Day 1 albumin level was predictive of 6-month patient life dependence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tseng, Chia-Cheng& Fang, Wen-Feng& Leung, Sum-Yee& Chen, Hung-Chen& Chang, Ya-Chun& Wang, Chin-Chou…[et al.]. 2014. Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome. Disease Markers،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tseng, Chia-Cheng…[et al.]. Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome. Disease Markers No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-499401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tseng, Chia-Cheng& Fang, Wen-Feng& Leung, Sum-Yee& Chen, Hung-Chen& Chang, Ya-Chun& Wang, Chin-Chou…[et al.]. Impact of Serum Biomarkers and Clinical Factors on Intensive Care Unit Mortality and 6-Month Outcome in Relatively Healthy Patients with Severe Pneumonia and Acute Respiratory Distress Syndrome. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-499401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر