Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells
المؤلفون المشاركون
Bukoreshtliev, Nickolay Vassilev
Eichler, Tilo Wolf
Gerdes, Hans-Hermann
Eifart, Patricia
Hodneland, Erlend
Rustom, Amin
المصدر
International Journal of Cell Biology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-06
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
The biogenesis, maturation, and exocytosis of secretory granules in interphase cells have been well documented, whereas the distribution and exocytosis of these hormone-storing organelles during cell division have received little attention.
By combining ultrastructural analyses and time-lapse microscopy, we here show that, in dividing PC12 cells, the prominent peripheral localization of secretory granules is retained during prophase but clearly reduced during prometaphase, ending up with only few peripherally localized secretory granules in metaphase cells.
During anaphase and telophase, secretory granules exhibited a pronounced movement towards the cell midzone and, evidently, their tracks colocalized with spindle microtubules.
During cytokinesis, secretory granules were excluded from the midbody and accumulated at the bases of the intercellular bridge.
Furthermore, by measuring exocytosis at the single granule level, we showed, that during all stages of cell division, secretory granules were competent for regulated exocytosis.
In conclusion, our data shed new light on the complex molecular machinery of secretory granule redistribution during cell division, which facilitates their release from the F-actin-rich cortex and active transport along spindle microtubules.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bukoreshtliev, Nickolay Vassilev& Hodneland, Erlend& Eichler, Tilo Wolf& Eifart, Patricia& Rustom, Amin& Gerdes, Hans-Hermann. 2012. Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-499456
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bukoreshtliev, Nickolay Vassilev…[et al.]. Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells. International Journal of Cell Biology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-499456
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bukoreshtliev, Nickolay Vassilev& Hodneland, Erlend& Eichler, Tilo Wolf& Eifart, Patricia& Rustom, Amin& Gerdes, Hans-Hermann. Partitioning and Exocytosis of Secretory Granules during Division of PC12 Cells. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-499456
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499456
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر