What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?
المؤلفون المشاركون
Ramos, Rodrigo Nalio
Zelante, Bruna
Barbuto, José Alexandre M.
Moraes, Cristiano Jacob de
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-22
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Dendritic cells (DCs) are essential for the maintenance of homeostasis in the organism, and they do that by modulating lymphocyte priming, expansion, and response patterns according to signals they receive from the environment.
The induction of suppressive lymphocytes by DCs is essential to hinder the development of autoimmune diseases but can be reverted against homeostasis when in the context of neoplasia.
In this setting, the induction of suppressive or regulatory T cells contributes to the establishment of a state of tolerance towards the tumor, allowing it to grow unchecked by an otherwise functional immune system.
Besides affecting its local environment, tumor also has been described as potent sources of anti-inflammatory/suppressive factors, which may act systemically, generating defects in the differentiation and maturation of immune cells, far beyond the immediate vicinity of the tumor mass.
Cytokines, as IL-10 and TGF-beta, as well as cell surface molecules like PD-L1 and ICOS seem to be significantly involved in the redirection of DCs towards tolerance induction, and recent data suggest that tumor cells may, indeed, modulate distinct DCs subpopulations through the involvement of these molecules.
It is to be expected that the identification of such molecules should provide molecular targets for more effective immunotherapeutic approaches to cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ramos, Rodrigo Nalio& Moraes, Cristiano Jacob de& Zelante, Bruna& Barbuto, José Alexandre M.. 2013. What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-499517
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ramos, Rodrigo Nalio…[et al.]. What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?. Clinical and Developmental Immunology No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-499517
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ramos, Rodrigo Nalio& Moraes, Cristiano Jacob de& Zelante, Bruna& Barbuto, José Alexandre M.. What Are the Molecules Involved in Regulatory T-Cells Induction by Dendritic Cells in Cancer?. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-499517
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499517
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر