Exploring the Ligand-Protein Networks in Traditional Chinese Medicine : Current Databases, Methods, and Applications
المؤلفون المشاركون
Ma, Wanghao
Zhao, Mingzhu
Zhou, Qiang
Wei, Dong-Qing
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-02
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
The traditional Chinese medicine (TCM), which has thousands of years of clinical application among China and other Asian countries, is the pioneer of the “multicomponent-multitarget” and network pharmacology.
Although there is no doubt of the efficacy, it is difficult to elucidate convincing underlying mechanism of TCM due to its complex composition and unclear pharmacology.
The use of ligand-protein networks has been gaining significant value in the history of drug discovery while its application in TCM is still in its early stage.
This paper firstly surveys TCM databases for virtual screening that have been greatly expanded in size and data diversity in recent years.
On that basis, different screening methods and strategies for identifying active ingredients and targets of TCM are outlined based on the amount of network information available, both on sides of ligand bioactivity and the protein structures.
Furthermore, applications of successful in silico target identification attempts are discussed in detail along with experiments in exploring the ligand-protein networks of TCM.
Finally, it will be concluded that the prospective application of ligand-protein networks can be used not only to predict protein targets of a small molecule, but also to explore the mode of action of TCM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Mingzhu& Zhou, Qiang& Ma, Wanghao& Wei, Dong-Qing. 2013. Exploring the Ligand-Protein Networks in Traditional Chinese Medicine : Current Databases, Methods, and Applications. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-499522
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Mingzhu…[et al.]. Exploring the Ligand-Protein Networks in Traditional Chinese Medicine : Current Databases, Methods, and Applications. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-499522
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Mingzhu& Zhou, Qiang& Ma, Wanghao& Wei, Dong-Qing. Exploring the Ligand-Protein Networks in Traditional Chinese Medicine : Current Databases, Methods, and Applications. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-499522
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499522
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر