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Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis
المؤلفون المشاركون
Slomiany, Amalia
SLomiany, Bronislaw L.
المصدر
International Journal of Inflammation
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Disturbances in nitric oxide synthase isozyme system and the impairment in salivary mucin synthesis are well-recognized features associated with oral mucosal inflammatory responses to periodontopathic bacterium, P.
gingivalis.
In this study, using rat sublingual gland acinar cells, we report that P.
gingivalis LPS-induced impairment in mucin synthesis and associated suppression in Akt kinase activity were accompanied by a decrease in constitutive nitric oxide synthase (cNOS) activity and an induction in inducible nitric oxide synthase (iNOS) expression.
The LPS effect on Akt inactivation was manifested in the kinase S-nitrosylation and a decrease in its phosphorylation at Ser473.
Further, we demonstrate that a peptide hormone, ghrelin, countered the LPS-induced impairment in mucin synthesis.
This effect of ghrelin was reflected in the suppression of iNOS and the increase in Akt activation, associated with the loss in S-nitrosylation and the increase in phosphorylation, as well as cNOS activation through phosphorylation.
Our findings suggest that induction in iNOS expression by P.
gingivalis-LPS leads to Akt kinase inactivation through S-nitrosylation that detrimentally impacts cNOS activation through phosphorylation as well as mucin synthesis.
We also show that the countering effect of ghrelin on P.
gingivalis-induced impairment in mucin synthesis is associated with Akt activation through phosphorylation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
SLomiany, Bronislaw L.& Slomiany, Amalia. 2011. Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis. International Journal of Inflammation،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499639
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
SLomiany, Bronislaw L.& Slomiany, Amalia. Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis. International Journal of Inflammation No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-499639
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
SLomiany, Bronislaw L.& Slomiany, Amalia. Ghrelin Protects against the Detrimental Consequences of Porphyromonas gingivalis-Induced Akt Inactivation through S-Nitrosylation on Salivary Mucin Synthesis. International Journal of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-499639
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499639
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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