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The Oncoplacental Gene Placenta-Specific Protein 1 Is Highly Expressed in Endometrial Tumors and Cell Lines
المؤلفون المشاركون
Leslie, Kimberly K.
Devor, Eric J.
المصدر
Obstetrics and Gynecology International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-07-10
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Placenta-specific protein 1 (PLAC1) is a small secreted protein expressed exclusively in trophoblast cells in the mammalian placenta.
PLAC1 is expressed early in gestation and is maintained throughout.
It is thought to function in trophoblast invasion of the uterine epithelium and, subsequently, to anchor the placenta to the epithelium.
In recent years, evidence has accumulated that PLAC1 is also expressed in a variety of human solid tumors, notably in breast cancers.
We demonstrate for the first time that PLAC1 is ubiquitously expressed in tumors originating in uterine epithelium.
Further, we find that PLAC1 expression is significantly higher in the more advanced, more aggressive endometrial serous adenocarcinomas and carcinosarcomas relative to endometrioid adenocarcinomas by more than 6-fold and 16-fold, respectively.
We also show that PLAC1 is simultaneously transcribed from two promoters but that, in all cases, the more distal P1 promoter dominates the more proximal P2 promoter.
While the function of the two PLAC1 promoters and their regulation are as yet unknown, overall expression data suggest that PLAC1 may serve as a biomarker for endometrial cancer as well as a potential prognostic indicator.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Devor, Eric J.& Leslie, Kimberly K.. 2013. The Oncoplacental Gene Placenta-Specific Protein 1 Is Highly Expressed in Endometrial Tumors and Cell Lines. Obstetrics and Gynecology International،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-499689
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Devor, Eric J.& Leslie, Kimberly K.. The Oncoplacental Gene Placenta-Specific Protein 1 Is Highly Expressed in Endometrial Tumors and Cell Lines. Obstetrics and Gynecology International No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-499689
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Devor, Eric J.& Leslie, Kimberly K.. The Oncoplacental Gene Placenta-Specific Protein 1 Is Highly Expressed in Endometrial Tumors and Cell Lines. Obstetrics and Gynecology International. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-499689
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499689
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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