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Adjuvant Cardioprotection in Cardiac Surgery : Update
المؤلفون المشاركون
Wagner, Robert
Maruyama, Junko
Kruzliak, Peter
Nicovsky, Jiri
Piler, Pavel
Gabbasov, Zufar
Maruyama, Kazuo
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Cardiac surgery patients are now more risky in terms of age, comorbidities, and the need for complex procedures.
It brings about reperfusion injury, which leads to dysfunction and/or loss of part of the myocardium.
These groups of patients have a higher incidence of postoperative complications and mortality.
One way of augmenting intraoperative myocardial protection is the phenomenon of myocardial conditioning, elicited with brief nonlethal episodes of ischaemia-reperfusion.
In addition, drugs are being tested that mimic ischaemic conditioning.
Such cardioprotective techniques are mainly focused on reperfusion injury, a complex response of the organism to the restoration of coronary blood flow in ischaemic tissue, which can lead to cell death.
Extensive research over the last three decades has revealed the basic mechanisms of reperfusion injury and myocardial conditioning, suggesting its therapeutic potential.
But despite the enormous efforts that have been expended in preclinical studies, almost all cardioprotective therapies have failed in the third phase of clinical trials.
One reason is that evolutionary young cellular mechanisms of protection against oxygen handling are not very robust.
Ischaemic conditioning, which is among these, is also limited by this.
At present, the prevailing belief is that such options of treatment exist, but their full employment will not occur until subquestions and methodological issues with the transfer into clinical practice have been resolved.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wagner, Robert& Piler, Pavel& Gabbasov, Zufar& Maruyama, Junko& Maruyama, Kazuo& Nicovsky, Jiri…[et al.]. 2014. Adjuvant Cardioprotection in Cardiac Surgery : Update. BioMed Research International،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-499710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wagner, Robert…[et al.]. Adjuvant Cardioprotection in Cardiac Surgery : Update. BioMed Research International No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-499710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wagner, Robert& Piler, Pavel& Gabbasov, Zufar& Maruyama, Junko& Maruyama, Kazuo& Nicovsky, Jiri…[et al.]. Adjuvant Cardioprotection in Cardiac Surgery : Update. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-499710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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