Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome
المؤلفون المشاركون
Jandrasits, Christine
Mayer, Gert
Perco, Paul
Mayer, Bernd
Moenks, Konrad
Mühlberger, Irmgard
Oberbauer, Rainer
Bernthaler, Andreas
المصدر
International Journal of Nephrology
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-10-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
The cardiorenal syndrome refers to the coexistence of kidney and cardiovascular disease, where cardiovascular events are the most common cause of death in patients with chronic kidney disease.
Both, cardiovascular as well as kidney diseases have been extensively analyzed on a molecular level, resulting in molecular features and associated processes indicating a cross-talk of the two disease etiologies on a pathophysiological level.
In order to gain a comprehensive picture of molecular factors contributing to the bidirectional interplay between kidney and cardiovascular system, we mined the scientific literature for molecular features reported as associated with the cardiorenal syndrome, resulting in 280 unique genes/proteins.
These features were then analyzed on the level of molecular processes and pathways utilizing various types of protein interaction networks.
Next to well established molecular features associated with the renin-angiotensin system numerous proteins involved in signal transduction and cell communication were found, involving specific molecular functions covering receptor binding with natriuretic peptide receptor and ligands as well known example.
An integrated analysis of identified features pinpointed a protein interaction network involving mediators of hemodynamic change and an accumulation of features associated with the endothelin and VEGF signaling pathway.
Some of these features may function as novel therapeutic targets.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mühlberger, Irmgard& Moenks, Konrad& Bernthaler, Andreas& Jandrasits, Christine& Mayer, Bernd& Mayer, Gert…[et al.]. 2010. Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499814
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mühlberger, Irmgard…[et al.]. Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome. International Journal of Nephrology No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-499814
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mühlberger, Irmgard& Moenks, Konrad& Bernthaler, Andreas& Jandrasits, Christine& Mayer, Bernd& Mayer, Gert…[et al.]. Integrative Bioinformatics Analysis of Proteins Associated with the Cardiorenal Syndrome. International Journal of Nephrology. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-499814
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499814
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر