Tetrandrine Inhibits the Wntβ-Catenin Signalling Pathway and Alleviates Osteoarthritis : An In Vitro and In Vivo Study
المؤلفون المشاركون
Zhou, Xindie
Li, Weijun
Li, Jin
Jiang, Lifeng
Tao, Lijiang
Wu, Lidong
Bao, Jiapeng
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-03-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
There is currently no effective drug treatment for the early phase of osteoarthritis (OA), one of the most common senile diseases.
The goal of this study was to investigate the protective effect of the tetrandrine (Tet) on OA, in vitro and in vivo.
In an in vitro experiment, quantitative real-time polymerase chain reaction (qRT-PCR) was used to investigate changes in gene expression upon the addition of Tet in chondrocytes processed with IL-1β; changes in protein profiles were assessed by Western blotting.
In vivo, to determine whether Tet has the protective effects on articular cartilage, a rabbit anterior cruciate ligament transaction model of OA was established.
Expression of matrix metalloproteinase and β-catenin genes increased significantly, while that of tissue inhibitor of metalloproteinase-1 decreased significantly in the OA group both in vivo and in chondrocytes.
However, the changes of expression were reversed by Tet, and there was less cartilage degradation in vivo compared with the OA group, as assessed by histological and macroscopic observations.
Thus, Tet may play a useful role in the treatment of OA through the Wnt/β-catenin signalling pathway and has potential for the treatment of OA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Xindie& Li, Weijun& Jiang, Lifeng& Bao, Jiapeng& Tao, Lijiang& Li, Jin…[et al.]. 2013. Tetrandrine Inhibits the Wntβ-Catenin Signalling Pathway and Alleviates Osteoarthritis : An In Vitro and In Vivo Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-499845
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Xindie…[et al.]. Tetrandrine Inhibits the Wntβ-Catenin Signalling Pathway and Alleviates Osteoarthritis : An In Vitro and In Vivo Study. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-499845
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Xindie& Li, Weijun& Jiang, Lifeng& Bao, Jiapeng& Tao, Lijiang& Li, Jin…[et al.]. Tetrandrine Inhibits the Wntβ-Catenin Signalling Pathway and Alleviates Osteoarthritis : An In Vitro and In Vivo Study. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-499845
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499845
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر