![](/images/graphics-bg.png)
Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate
المؤلفون المشاركون
Aboul-Fadl, Tarek
Darwish, Ibrahim A.
Khalil, Nasr Y.
Mahmoud, Ashraf M.
المصدر
International Journal of Analytical Chemistry
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-01-25
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
New selective and sensitive spectrophotometric and spectrofluorometric methods have been developed and validated for the determination of amantadine hydrochloride (AMD) in capsules and plasma.
The methods were based on the condensation of AMD with 1,2-naphthoquinone-4-sulphonate (NQS) in an alkaline medium to form an orange-colored product.
The spectrophotometric method involved the measurement of the colored product at 460 nm.
The spectrofluorometric method involved the reduction of the product with potassium borohydride, and the subsequent measurement of the formed fluorescent reduced AMD-NQS product at 382 nm after excitation at 293 nm.
The variables that affected the reaction were carefully studied and optimized.
Under the optimum conditions, linear relationships with good correlation coefficients (0.9972–0.9974) and low LOD (1.39 and 0.013 μg mL−1) were obtained in the ranges of 5–80 and 0.05–10 μg mL−1 for the spectrophotometric and spectrofluorometric methods, respectively.
The precisions of the methods were satisfactory; RSD ≤2.04%.
Both methods were successfully applied to the determination of AMD in capsules.
As its higher sensitivity, the spectrofluorometric method was applied to the determination of AMD in plasma; the recovery was 96.3–101.2±0.57–4.2%.
The results obtained by the proposed methods were comparable with those obtained by the official method
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mahmoud, Ashraf M.& Khalil, Nasr Y.& Darwish, Ibrahim A.& Aboul-Fadl, Tarek. 2009. Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. International Journal of Analytical Chemistry،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-499879
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mahmoud, Ashraf M.…[et al.]. Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. International Journal of Analytical Chemistry No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-499879
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mahmoud, Ashraf M.& Khalil, Nasr Y.& Darwish, Ibrahim A.& Aboul-Fadl, Tarek. Selective Spectrophotometric and Spectrofluorometric Methods for the Determination of Amantadine Hydrochloride in Capsules and Plasma via Derivatization with 1,2-Naphthoquinone-4-sulphonate. International Journal of Analytical Chemistry. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-499879
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499879
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)