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Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems
المؤلفون المشاركون
Carter, Phillip W.
Zhang, Yingqing
Patel, Dipa
Green, John-Bruce D.
Kotha, Priyanka
Gonyon, Thomas
المصدر
Journal of Analytical Methods in Chemistry
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-16
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Detailing the kinetics of particle formation for pharmaceutically relevant solutions is challenging, especially when considering the combination of formulations, containers, and timescales of clinical importance.
This paper describes a method for using commercial software Automate with a stream-selector valve capable of sampling container solutions from within an environmental chamber.
The tool was built to monitor changes in particle size distributions via instrumental particle counters but can be adapted to other solution-based sensors.
The tool and methodology were demonstrated to be highly effective for measuring dynamic changes in emulsion globule distributions as a function of storage and mixing conditions important for parenteral nutrition.
Higher levels of agitation induced the fastest growth of large globules (≥5 μm) while the gentler conditions actually showed a decrease in the number of these large globules.
The same methodology recorded calcium phosphate precipitation kinetics as a function of [Ca2+] and pH.
This automated system is readily adaptable to a wide range of pharmaceutically relevant systems where the particle size is expected to vary with time.
This instrumentation can dramatically reduce the time and resources needed to probe complex formulation issues while providing new insights for monitoring the kinetics as a function of key variables.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Green, John-Bruce D.& Carter, Phillip W.& Zhang, Yingqing& Patel, Dipa& Kotha, Priyanka& Gonyon, Thomas. 2014. Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499924
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Green, John-Bruce D.…[et al.]. Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-499924
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Green, John-Bruce D.& Carter, Phillip W.& Zhang, Yingqing& Patel, Dipa& Kotha, Priyanka& Gonyon, Thomas. Automated System for Kinetic Analysis of Particle Size Distributions for Pharmaceutically Relevant Systems. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-499924
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-499924
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