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Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers
المؤلفون المشاركون
Dorn, Cornelia
Fichtner, Iduna
Merk, Johannes
Rolff, Jana
المصدر
العدد
المجلد 2009، العدد 2009 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2009-06-14
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Tumor cells that are nonsensitive to anticancer drugs frequently have a multidrug resistant (MDR) phenotype.
Many studies with cell lines and patient material have been done to investigate the impact of different resistance markers at protein and mRNA level in drug resistance but with contradictory outcome.
In the present study, 26 well-characterised patient-derived non-small cell lung cancer xenografts were used.
The known chemosensitivity to etoposide, carboplatin, gemcitabine, paclitaxel and erlotinib was compared to the protein and mRNA expression of BCRP, LRP, MDR1, and MRP1.
Further, four of these xenografts were short-term treated to analyse possible regulation mechanisms after therapeutic interventions.
We found a borderline correlation between the bcrp mRNA expression and the response of xenografts to etoposide.
All other constitutive mRNA and protein expression levels were not correlated to any drug response and were not significantly influenced by a short term treatment.
The present results indicate that the expression levels of MDR proteins and mRNA investigated do not play an important role in the chemoresistance of NSCLC in the in vivo situation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rolff, Jana& Dorn, Cornelia& Merk, Johannes& Fichtner, Iduna. 2009. Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers. Journal of Oncology،Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-500178
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rolff, Jana…[et al.]. Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers. Journal of Oncology No. 2009 (2009), pp.1-6.
https://search.emarefa.net/detail/BIM-500178
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rolff, Jana& Dorn, Cornelia& Merk, Johannes& Fichtner, Iduna. Response of Patient-Derived Non-Small Cell Lung Cancer Xenografts to Classical and Targeted Therapies Is Not Related to Multidrug Resistance Markers. Journal of Oncology. 2009. Vol. 2009, no. 2009, pp.1-6.
https://search.emarefa.net/detail/BIM-500178
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500178
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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