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Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens
المؤلفون المشاركون
Huang, Weidong
Frankson, Kristi
Cook, Jennifer W.
Whitcomb, Jeannette M.
Winslow, John
Chen, Lili
Goodman, Laurie J.
Utter, Shannon
Parry, Gordon
Rivera, Amber
Irwin, Sarah
Larson, Jeffrey S.
Petropoulos, Christos J.
Bates, Michael
Cheung, Judy
Tan, Yuping
Defazio-Eli, Lisa
Shi, Yining
Sherwood, Thomas
Paquet, Agnes C.
Weidler, Jodi
Bose, Jolly
Kiss, Linda D. B.
المصدر
Pathology Research International
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-06-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
We report here the results of the analytical validation of assays that measure HER2 total protein (H2T) and HER2 homodimer (H2D) expression in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tumors as well as cell line controls.
The assays are based on the VeraTag technology platform and are commercially available through a central CAP-accredited clinical reference laboratory.
The accuracy of H2T measurements spans a broad dynamic range (2-3 logs) as evaluated by comparison with cross-validating technologies.
The measurement of H2T expression demonstrates a sensitivity that is approximately 7–10 times greater than conventional immunohistochemistry (IHC) (HercepTest).
The HERmark assay is a quantitative assay that sensitively and reproducibly measures continuous H2T and H2D protein expression levels and therefore may have the potential to stratify patients more accurately with respect to response to HER2-targeted therapies than current methods which rely on semiquantitative protein measurements (IHC) or on indirect assessments of gene amplification (FISH).
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Larson, Jeffrey S.& Goodman, Laurie J.& Tan, Yuping& Defazio-Eli, Lisa& Paquet, Agnes C.& Cook, Jennifer W.…[et al.]. 2010. Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens. Pathology Research International،Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-500185
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Larson, Jeffrey S.…[et al.]. Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens. Pathology Research International No. 2010 (2010), pp.1-14.
https://search.emarefa.net/detail/BIM-500185
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Larson, Jeffrey S.& Goodman, Laurie J.& Tan, Yuping& Defazio-Eli, Lisa& Paquet, Agnes C.& Cook, Jennifer W.…[et al.]. Analytical Validation of a Highly Quantitative, Sensitive, Accurate, and Reproducible Assay (HERmark®) for the Measurement of HER2 Total Protein and HER2 Homodimers in FFPE Breast Cancer Tumor Specimens. Pathology Research International. 2010. Vol. 2010, no. 2010, pp.1-14.
https://search.emarefa.net/detail/BIM-500185
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-500185
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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